Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier. (Q38166961)

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scientific article published on March 2013

Language	Label	Description	Also known as
English	Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.	scientific article published on March 2013

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

blood–brain barrier

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based on heuristic

inferred from title

3

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1 March 2020

Severin Mairinger

2

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1 March 2020

author name string

Thomas Wanek

1

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1 March 2020

language of work or name

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based on heuristic

inferred from title

publication date

1 March 2013

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1 March 2020

Journal of Labelled Compounds and Radiopharmaceuticals

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1 March 2020

56

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1 March 2020

3-4

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1 March 2020

68-77

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1 March 2020

PET radiotracers: crossing the blood-brain barrier and surviving metabolism

1 reference

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21 January 2018

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

1 reference

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21 January 2018

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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21 January 2018

ABCG2: a perspective.

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21 January 2018

A family of drug transporters: the multidrug resistance-associated proteins.

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21 January 2018

On the rate and extent of drug delivery to the brain.

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21 January 2018

Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected

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ABCB1: the role in Parkinson's disease and pharmacokinetics of antiparkinsonian drugs

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

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Targeting multidrug resistance in cancer

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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21 January 2018

Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

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21 January 2018

Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages.

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21 January 2018

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

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21 January 2018

Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

1 reference

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21 January 2018

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

1 reference

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21 January 2018

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

1 reference

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21 January 2018

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide

1 reference

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21 January 2018

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

1 reference

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21 January 2018

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

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21 January 2018

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

1 reference

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21 January 2018

Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET.

1 reference

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21 January 2018

An improved method for the preparation of [11C]verapamil

1 reference

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21 January 2018

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

1 reference

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21 January 2018

Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

1 reference

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21 January 2018

(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

1 reference

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21 January 2018

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

1 reference

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21 January 2018

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FJLCR.2993

21 January 2018

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

1 reference

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21 January 2018

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

1 reference

https://api.crossref.org/works/10.1002%2FJLCR.2993

21 January 2018

Blood-brain barrier P-glycoprotein function in Alzheimer's disease

1 reference

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21 January 2018

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

1 reference

https://api.crossref.org/works/10.1002%2FJLCR.2993

21 January 2018

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

1 reference

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21 January 2018

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux

1 reference

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21 January 2018

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

1 reference

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21 January 2018

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys

1 reference

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21 January 2018

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

1 reference

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21 January 2018

Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice

1 reference

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21 January 2018

High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.

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21 January 2018

Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

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21 January 2018

Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar

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21 January 2018

Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening.

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21 January 2018

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

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Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression.

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21 January 2018

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

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Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar

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21 January 2018

Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET.

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21 January 2018

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

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A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier

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21 January 2018

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

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Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

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Evaluation of limiting brain penetration related to P-glycoprotein and breast cancer resistance protein using [(11)C]GF120918 by PET in mice

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The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier

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Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

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Identifiers

10.1002/JLCR.2993

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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