Revisiting the role of the granuloma in tuberculosis (Q38003929)

26 August 2017

title

Revisiting the role of the granuloma in tuberculosis (English)

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26 August 2017

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Lalita Ramakrishnan

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26 August 2017

publication date

20 April 2012

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Nature Reviews Immunology

26 August 2017

published in

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26 August 2017

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26 August 2017

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26 August 2017

page(s)

352-366

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Richard Morton (1637-98) and his Phthisiologia

26 August 2017

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Corpse clearance defines the meaning of cell death

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Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish

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Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection.

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Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

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Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.

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Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms

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Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function

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Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection.

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Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection

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Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo

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High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation

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Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections

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Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence

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A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion

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Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis

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Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis.

21 January 2018

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The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression

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Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin

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Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

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Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells

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The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis

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Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

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CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis

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A replication clock for Mycobacterium tuberculosis

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Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages

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Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo

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Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma

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Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis

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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

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Identification of nitric oxide synthase as a protective locus against tuberculosis

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Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

21 January 2018

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Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.

21 January 2018

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Indoleamine 2,3-dioxygenase and tumor-induced tolerance

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A role for IL-18 in protective immunity against Mycobacterium tuberculosis

21 January 2018

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Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis

21 January 2018

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The adaptor molecule CARD9 is essential for tuberculosis control

21 January 2018

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Who puts the tubercle in tuberculosis?

21 January 2018

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Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

21 January 2018

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Expression of matrix metalloproteinases in patients with Wegener's granulomatosis

21 January 2018

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Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases

21 January 2018

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Identification of the uncultured bacillus of Whipple's disease

21 January 2018

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Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease

21 January 2018

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Lessons from experimental Mycobacterium tuberculosis infections

21 January 2018

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Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts.

21 January 2018

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Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis

21 January 2018

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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

21 January 2018

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Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

21 January 2018

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IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection

21 January 2018

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Relative importance of STAT4 in murine tuberculosis

31 March 2020

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Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis

31 March 2020

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Images in clinical medicine. Mycobacterium marinum infection of the hand

31 March 2020

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Dynamic imaging of T cell-dendritic cell interactions in lymph nodes

31 March 2020

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Paradoxical response to antituberculous therapy in infliximab-treated patients with disseminated tuberculosis

31 March 2020

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Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis

31 March 2020

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TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-gamma independent manner

31 March 2020

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Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

31 March 2020

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ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors

31 March 2020

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Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis

31 March 2020

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Trafficking and release of mycobacterial lipids from infected macrophages

31 March 2020

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Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice

31 March 2020

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Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family

31 March 2020

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The granulomatous inflammatory response. A review

31 March 2020

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12 December 2020

Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes

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12 December 2020

The granulomatous inflammatory exudate

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12 December 2020

Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection

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12 December 2020

The structure of mononuclear phagocytes differentiating in vivo. I. Sequential fine and histologic studies of the effect of Bacillus Calmette-Guerin (BCG).

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12 December 2020

The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis.

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12 December 2020

Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model

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12 December 2020

Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection

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12 December 2020

Programmed cell death of Mycobacterium avium serovar 4-infected human macrophages prevents the mycobacteria from spreading and induces mycobacterial growth inhibition by freshly added, uninfected macrophages

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12 December 2020

Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.

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12 December 2020

The residual infectivity of the primary complex of tuberculosis

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12 December 2020

IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis

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12 December 2020

Granuloma formation in severe combined immunodeficient (SCID) mice in response to progressive BCG infection. Tendency not to form granulomas in the lung is associated with faster bacterial growth in this organ

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12 December 2020

Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.

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12 December 2020

Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.

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12 December 2020

Reversible roentgenographic progression in the initial treatment of pulmonary tuberculosis

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12 December 2020

Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis

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12 December 2020

Tuberculosis and granuloma formation in patients receiving anti-TNF therapy

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12 December 2020

The structure and function of monocytes and macrophages

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12 December 2020

Identifiers

DOI

10.1038/NRI3211

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Dimensions Publication ID

26 August 2017

1021041250

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