Pathogenesis of severe asthma. (Q38003659)

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scientific article published on May 2012

Language	Label	Description	Also known as
English	Pathogenesis of severe asthma.	scientific article published on May 2012

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22515387%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Pathogenesis of severe asthma (English)

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Europe PubMed Central

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29 January 2020

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Catherine Laprise

4

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29 January 2020

author name string

A H Poon

1

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29 January 2020

D H Eidelman

2

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29 January 2020

J G Martin

3

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29 January 2020

Q Hamid

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29 January 2020

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1 May 2012

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29 January 2020

Clinical & Experimental Allergy

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29 January 2020

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29 January 2020

5

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29 January 2020

625-637

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29 January 2020

Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program

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21 January 2018

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

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21 January 2018

Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines

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21 January 2018

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

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21 January 2018

Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies

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21 January 2018

Eosinophils: biological properties and role in health and disease

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21 January 2018

Mepolizumab and exacerbations of refractory eosinophilic asthma

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21 January 2018

Cluster analysis and clinical asthma phenotypes.

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21 January 2018

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma

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Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

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Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance

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21 January 2018

Association between neutrophilic airway inflammation and airflow limitation in adults with asthma.

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21 January 2018

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

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21 January 2018

Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma

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21 January 2018

Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation

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21 January 2018

Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

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21 January 2018

Relationship of small airway chymase-positive mast cells and lung function in severe asthma

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21 January 2018

Remodeling in asthma

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21 January 2018

T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma

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21 January 2018

Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression

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21 January 2018

Differences in airway remodeling between subjects with severe and moderate asthma

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21 January 2018

Differences in airway cytokine profile in severe asthma compared to moderate asthma.

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21 January 2018

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

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21 January 2018

IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression

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21 January 2018

Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations

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21 January 2018

Untangling the complex web of IL-4- and IL-13-mediated signaling pathways

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21 January 2018

Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma

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21 January 2018

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

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21 January 2018

Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

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21 January 2018

STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease

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21 January 2018

STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease

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21 January 2018

Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

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21 January 2018

Regulation of Th2 differentiation and Il4 locus accessibility.

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21 January 2018

Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway.

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21 January 2018

Importance of cytokines in murine allergic airway disease and human asthma

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21 January 2018

Inflammatory and remodeling events in asthma with chronic exposure to house dust mites: a murine model

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21 January 2018

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.

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21 January 2018

Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling

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21 January 2018

Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study

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21 January 2018

Increased levels of osteopontin in sputum supernatant in severe refractory asthma

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21 January 2018

Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma.

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21 January 2018

Lebrikizumab Treatment in Adults with Asthma

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21 January 2018

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

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21 January 2018

IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells

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21 January 2018

Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma

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21 January 2018

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

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21 January 2018

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

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21 January 2018

Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation

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21 January 2018

Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse.

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21 January 2018

A chitinase-like protein in the lung and circulation of patients with severe asthma

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21 January 2018

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function

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21 January 2018

Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.

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21 January 2018

The basics of epithelial-mesenchymal transition

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21 January 2018

IL-5 and eosinophilia.

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21 January 2018

Interleukin 5 in the link between the innate and acquired immune response

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21 January 2018

Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice

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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

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21 January 2018

Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients.

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21 January 2018

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

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21 January 2018

IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.

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21 January 2018

Increased IL-33 expression by epithelial cells in bronchial asthma.

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21 January 2018

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

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The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene Transcription

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21 January 2018

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket

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21 January 2018

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

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21 January 2018

IL-33 family members and asthma - bridging innate and adaptive immune responses.

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21 January 2018

IL-33 and IL-33 receptors in host defense and diseases

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21 January 2018

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

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21 January 2018

A large-scale, consortium-based genomewide association study of asthma

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21 January 2018

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

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21 January 2018

IL-33 mediates inflammatory responses in human lung tissue cells

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21 January 2018

IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation

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21 January 2018

IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?

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21 January 2018

Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome

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21 January 2018

Severe asthma: from characteristics to phenotypes to endotypes

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21 January 2018

TH17 cells in asthma and inflammation

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21 January 2018

Distinct regulation of interleukin-17 in human T helper lymphocytes

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21 January 2018

Development, cytokine profile and function of human interleukin 17-producing helper T cells

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21 January 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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21 January 2018

IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1

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21 January 2018

Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis

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21 January 2018

Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family

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21 January 2018

Structure and signalling in the IL-17 receptor family

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21 January 2018

Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy

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21 January 2018

Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells

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21 January 2018

Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.

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21 January 2018

Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response

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21 January 2018

Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness

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21 January 2018

Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation

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21 January 2018

The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.

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21 January 2018

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

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21 January 2018

IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts

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21 January 2018

The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis.

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21 January 2018

The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population

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21 January 2018

T-bet in disease.

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21 January 2018

Regulation of interferon-gamma during innate and adaptive immune responses

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21 January 2018

Demonstration and partial characterization of the interferon-gamma receptor on human mononuclear phagocytes

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21 January 2018

Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma

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21 January 2018

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases

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21 January 2018

IFNgamma signaling-does it mean JAK-STAT?

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21 January 2018

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma

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21 January 2018

Effect of interferon-gamma on allergic airway responses in interferon-gamma-deficient mice

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21 January 2018

Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways.

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21 January 2018

Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma.

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21 January 2018

Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma

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21 January 2018

Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis

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21 January 2018

Endotoxins, asthma, and allergic immune responses

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21 January 2018

Importance of IL-18-induced super Th1 cells for the development of allergic inflammation

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21 January 2018

T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production

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21 January 2018

Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse

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21 January 2018

Detection of immunological biomarkers correlated with asthma control and quality of life measurements in sera from chronic asthmatic patients

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21 January 2018

Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma

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21 January 2018

Mechanisms and resistance in glucocorticoid control of inflammation

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21 January 2018

Primary structure and expression of a functional human glucocorticoid receptor cDNA

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21 January 2018

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans

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21 January 2018

The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Long-range regulation of cytokine gene expression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

Long-range chromosomal interactions and gene regulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2222.2012.03983.X

21 January 2018

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