Clinical significance of pharmacokinetic models of hepatic elimination (Q37905439)

25 August 2017

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title

Clinical significance of pharmacokinetic models of hepatic elimination (English)

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25 August 2017

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Morgan DJ

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25 August 2017

Smallwood RA

series ordinal

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25 August 2017

publication date

1 January 1990

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Clinical Pharmacokinetics

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

61-76

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Stable oral availability of sustained release propranolol when co-administered with hydralazine or food: evidence implicating substrate delivery rate as a determinant of presystemic drug interactions

25 August 2017

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Theoretical Michaelis-Menten elimination model for propranolol

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Interaction between oral propranolol and hydralazine

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Hepatic vascular bed.

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Functional implications of liver cell heterogeneity.

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Drugs as indicators of hepatic function.

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LIVER BLOOD FLOW IN PREGNANCY-HEPATIC VEIN CATHETERIZATION.

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A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

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Drug interactions involving the displacement of drugs from plasma protein and tissue binding sites

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Effects of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine

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12 December 2020

Exact mathematical equivalence of the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model

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Presence of a diffusional barrier on metabolite kinetics: enalaprilat as a generated versus preformed metabolite

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12 December 2020

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12 December 2020

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Environmental factors affecting drug metabolism

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Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models

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Hepatic drug metabolism in the elderly

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12 December 2020

Drug metabolism in the elderly

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12 December 2020

Protein binding drug displacement interactions fact or fiction?

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Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

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Influence of route of hepatic administration on drug availability.

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Heterogeneous intrahepatic distribution of blood flow in humans

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Commentary: a physiological approach to hepatic drug clearance

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Hepatic clearance and liver blood flow

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12 December 2020

Reduction of first-pass hepatic clearance of propranolol by food

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12 December 2020

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Alpha 1 -acid glycoprotein and binding of basic drugs

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12 December 2020

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12 December 2020

A simulation study on the effect of a uniform diffusional barrier across hepatocytes on drug metabolism by evenly or unevenly distributed uni-enzyme in the liver

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12 December 2020

Propranolol: pooled Michaelis-Menten parameters and the effect of input rate on bioavailability.

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12 December 2020

Clearance concepts in pharmacokinetics

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12 December 2020

Hepatic Clearance Measurements and Pharmacokinetics

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12 December 2020

Nonlinear pharmacokinetics of unbound propranolol after oral administration

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12 December 2020

The impairment of lignocaine clearance by propranolol--major contribution from enzyme inhibition

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12 December 2020

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

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12 December 2020

Intrinsic hepatic clearance and Child-Turcotte classification for assessment of liver function in cirrhosis

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12 December 2020

Lumpers vs. distributers

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12 December 2020

Hepatic disease and drug pharmacokinetics

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12 December 2020

Disease-induced changes in the plasma binding of basic drugs

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12 December 2020

Autoradiographic evidence for hepatic lobular concentration gradient of bile acid derivative

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12 December 2020

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

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12 December 2020

Theoretical decrease in systemic availability with decrease in input rate at steady-state for first-pass drugs

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12 December 2020

The terminal hepatic microcirculation in the rat

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12 December 2020

Influence of Food Intake on Presystemic Clearance of Drugs

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12 December 2020

Intrinsic hepatic clearance in cirrhosis

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12 December 2020

Clearly There is Intrinsic Value in Intrinsic Clearance

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12 December 2020

Mechanism for reduced drug clearance in patients with cirrhosis

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12 December 2020

Lidocaine elimination: effects of metoprolol and of propranolol

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12 December 2020

Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism

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12 December 2020

Enzymatic elimination of substrates flowing through the intact liver

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12 December 2020

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

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12 December 2020

Interindividual differences in amitriptyline demethylation

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12 December 2020

Propranolol disposition in chronic liver disease: a physiological approach

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12 December 2020

Influence of age and smoking on drug kinetics in man: studies using model compounds

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12 December 2020

Bioavailability of sustained release propranolol formulations

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12 December 2020

Determinants of drug disposition in patients with cirrhosis

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12 December 2020

Clinical Implications of Enzyme Induction and Enzyme Inhibition

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12 December 2020

Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways

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12 December 2020

The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

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12 December 2020

Effects of smoking and chronic hepatitis B on lidocaine and indocyanine green kinetics

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12 December 2020

Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man.

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12 December 2020

The series-compartment model for hepatic elimination.

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12 December 2020

Paracetamol metabolism in pregnancy

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12 December 2020

Phenytoin metabolism in the rat. Pharmacokinetic correlation between in vitro hepatic microsomal enzyme activity and in vivo elimination kinetics

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12 December 2020

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

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12 December 2020

The effect of oral protein and glucose feeding of splanchnic blood flow and oxygen utilization in normal and cirrhotic subjects

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12 December 2020

Influence of food on the presystemic metabolism of drugs

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12 December 2020

Hepatic transport kinetics and plasma disappearance curves: distributed modeling versus conventional approach

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12 December 2020

Increased oral clearance of metoprolol in pregnancy

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12 December 2020

Free drug concentration monitoring in clinical practice. Rationale and current status

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12 December 2020

Comparison of nonlinear pharmacokinetic parameters estimated from the sinusoidal perfusion and venous equilibrium models.

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12 December 2020

Influence of posture on hepatic perfusion and the presystemic biotransformation of propranolol: simulation of the food effect

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12 December 2020

Theoretic aspects of pharmacokinetic drug interactions

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12 December 2020

Effect of carbohydrates on estimated hepatic blood flow

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12 December 2020

Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol

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12 December 2020

Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis

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12 December 2020

Altered Hepatic Blood Flow and Drug Disposition1

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12 December 2020

Hepatic uptake of propranolol.

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12 December 2020

Drug Metabolism by the Gastrointestinal Mucosa

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12 December 2020

Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases

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12 December 2020

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine

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12 December 2020

Noninvasive kinetic approach to the estimation of total hepatic blood flow and shunting in chronic liver disease--a hypothesis

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12 December 2020

10.2165/00003088-199018010-00004

Identifiers

DOI

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Dimensions Publication ID

25 August 2017

1011218942

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