Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain (Q37278215)

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scientific article published on 24 September 2008

Language	Label	Description	Also known as
English	Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain	scientific article published on 24 September 2008

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

1 reference

Europe PubMed Central

Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain (English)

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Europe PubMed Central

PubMed publication ID

19 August 2017

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based on heuristic

inferred from title

cancer metastasis

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Cimona V Hinton

object named as

Cimona V Hinton

1

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Hava Karsenty Avraham

object named as

Hava Karsenty Avraham

3

0 references

author name string

Shalom Avraham

2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

24 September 2008

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

Clinical & Experimental Metastasis

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Europe PubMed Central

PubMed publication ID

19 August 2017

27

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

97-105

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Europe PubMed Central

PubMed publication ID

19 August 2017

Tumor metastasis to brain: role of endothelial cells, neurotrophins, and paracrine growth factors

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9210-2

21 January 2018

Breast cancer metastasis to the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9210-2

21 January 2018

Early phase I data on an irreversible pan-erb inhibitor: CI-1033. What did we learn?

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9210-2

21 January 2018

Vascular endothelial growth factor in CSF: a biological marker for carcinomatous meningitis

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9210-2

21 January 2018

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The risk of central nervous system metastases after trastuzumab therapy in patients with breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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The pro-inflammatory seven-transmembrane segment receptors of the leukocyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor is a potential therapeutic target in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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Chemoattractant signaling and leukocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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Wound repair: the role of cytokines and vasoactive mediators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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A gene expression signature associated with metastatic cells in effusions of breast carcinoma patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

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Nerve growth factor-induced migration of endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemokines: cytokines that direct leukocyte migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and structure of a pre-B-cell growth-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung metastasis genes couple breast tumor size and metastatic spread.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis and Management of Central Nervous System Metastases from Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine networks and breast cancer metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metastases in breast cancer; natural history, prognostic factors and outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stromal effects on mammary gland development and breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breakdown of the Blood–Brain Barrier After Fluid Percussion Brain Injury in the Rat: Part 2: Effect of Hypoxia on Permeability to Plasma Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor mediates its pro-invasive effect in parallel with the release of a soluble E-cadherin fragment from breast cancer MCF-7/AZ cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor receptors and signaling in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptor CXCR4 expression in endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCR4 is a major chemokine receptor on glioma cells and mediates their survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multigenic program mediating breast cancer metastasis to bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid increase in blood-brain barrier permeability during severe hypoxia and metabolic inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer brain metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of vascular endothelial growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lapatinib: a dual inhibitor of EGFR and HER2 tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Not so strange bedfellows: G-protein-coupled receptors and Src family kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines--chemotactic cytokines that mediate inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines and their receptors in lymphocyte traffic and HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of chemokine receptors in breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of ErbB1 and ErbB2 receptors by angiotensin II in normal human prostate stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR signal transactivation in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HER2 in brain metastases: issues of concordance, survival, and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metastases from breast cancer: clinical course, prognosis and influence of treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous system metastasis in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo selection for metastasis promoting genes in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines, inflammation and the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structures of alpha and beta chemokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oestrogen receptors, sites of metastatic disease and survival in recurrent breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS metastases in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human chemokines: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines and leukocyte traffic

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer and the chemokine network

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor overexpression and autocrine loop in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptors: gateways to inflammation and infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor (VEGF) and its receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokines: a new classification system and their role in immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of the tumor microenvironment in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18814042

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10585-008-9210-2

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 August 2017

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