Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants. (Q36911645)

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scientific article published on 6 March 2013

Language	Label	Description	Also known as
English	Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.	scientific article published on 6 March 2013

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scholarly article

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25 February 2020

Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants (English)

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25 February 2020

G protein-coupled receptor

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3

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25 February 2020

Bartosz Trzaskowski

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25 February 2020

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25 February 2020

Thomas P Sakmar

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Per Johan Klasse

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Per Johan Klasse

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John P Moore

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Reem Berro

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Anila Yasmeen

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Sarya Abi-Habib

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Amy Grunbeck

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William A Goddard

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6 March 2013

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Journal of Virology

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6569-6581

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25 February 2020

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11 June 2022

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Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

1 reference

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Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.

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Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.

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HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay

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29 September 2017

Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor

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HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry

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Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry

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A pièce de resistance: how HIV-1 escapes small molecule CCR5 inhibitors

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Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120.

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Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists

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Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

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29 September 2017

Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

1 reference

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29 September 2017

Interaction of small molecule inhibitors of HIV-1 entry with CCR5.

1 reference

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29 September 2017

Structure of a V3-containing HIV-1 gp120 core

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Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D).

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The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors

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HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.

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4 September 2018

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10.1128/JVI.00099-13

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