Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma (Q36891532)

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scientific article published on 4 September 2008

Language	Label	Description	Also known as
English	Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma	scientific article published on 4 September 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma (English)

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Europe PubMed Central

PMC publication ID

16 August 2017

Carol Feghali-Bostwick

11

object named as

Carol Feghali-Bostwick

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Europe PubMed Central

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16 August 2017

Gabriella Lakos

6

object named as

Gabriella Lakos

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16 August 2017

author name string

Swati Bhattacharyya

1

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16 August 2017

Shu-Jen Chen

2

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16 August 2017

Minghua Wu

3

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Europe PubMed Central

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16 August 2017

Matthew Warner-Blankenship

4

1 reference

Europe PubMed Central

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16 August 2017

Hongyan Ning

5

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16 August 2017

Yasuji Mori

7

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16 August 2017

Eric Chang

8

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16 August 2017

Chihiro Nihijima

9

1 reference

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16 August 2017

Kazuhiro Takehara

10

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16 August 2017

John Varga

12

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16 August 2017

language of work or name

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publication date

4 September 2008

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16 August 2017

The American Journal of Pathology

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16 August 2017

173

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Europe PubMed Central

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16 August 2017

4

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Europe PubMed Central

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16 August 2017

1085-1099

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Europe PubMed Central

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16 August 2017

Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Molecular pathways as novel therapeutic targets in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Early growth response factor-1 in acute lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis

1 reference

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29 September 2017

MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production

1 reference

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29 September 2017

Systemic sclerosis: a prototypic multisystem fibrotic disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.

1 reference

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29 September 2017

Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail

1 reference

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29 September 2017

Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth

1 reference

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29 September 2017

The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Early growth response-1 in cardiovascular pathobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Smad transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Transforming growth factor-beta: a key mediator of fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Non-Smad TGF-beta signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

c-Abl regulates early growth response protein (EGR1) in response to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Animal models in scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease

1 reference

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29 September 2017

Cyclosporine modulates the response to hypoxia-reoxygenation in pulmonary artery endothelial cells

1 reference

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29 September 2017

HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1.

1 reference

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29 September 2017

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis

1 reference

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29 September 2017

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

1 reference

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29 September 2017

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Ets ternary complex transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Egr-1 target genes in human endothelial cells identified by microarray analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Systemic and cell type-specific gene expression patterns in scleroderma skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Regulation of life and death by the zinc finger transcription factor Egr-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

29 September 2017

The effect of anti-inflammatory properties of mycophenolate mofetil on the development of lung reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

27 June 2018

Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

27 June 2018

Expression of Egr-1 in late stage emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

27 June 2018

NAB2: a transcriptional brake for activated gene expression in the vessel wall?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

27 June 2018

MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Animal models of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Stimulation of the murine type II transforming growth factor-beta receptor promoter by the transcription factor Egr-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Bleomycin upregulates gene expression of angiotensin-converting enzyme via mitogen-activated protein kinase and early growth response 1 transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2543076

4 September 2018

Role of p38 MAPK in Transforming Growth Factor β Stimulation of Collagen Production by Scleroderma and Healthy Dermal Fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator p

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18772333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2008.080382

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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