Structure and function of the atypical orphan nuclear receptor small heterodimer partner (Q36845708)

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scientific article published on January 2007

Language	Label	Description	Also known as
English	Structure and function of the atypical orphan nuclear receptor small heterodimer partner	scientific article published on January 2007

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

1 reference

Europe PubMed Central

Structure and function of the atypical orphan nuclear receptor small heterodimer partner (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

author name string

Yong-Soo Lee

1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Dipanjan Chanda

2

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Jeonggu Sim

3

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Yun-Yong Park

4

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Hueng-Sik Choi

5

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

publication date

1 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

International Review of Cytology

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

261

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

117-158

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Nuclear hormone receptors and gene expression

1 reference

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Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

1 reference

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A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP

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Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

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Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

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Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

1 reference

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

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The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Identification of polymorphisms in the human SHP1 gene

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Nuclear receptors and lipid physiology: opening the X-files

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Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter

1 reference

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The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun

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Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake

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Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats

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The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis

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Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription

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Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

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Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

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Estrogen receptor alpha inhibits IL-1beta induction of gene expression in the mouse liver

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The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

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Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

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Orphan nuclear receptors: from gene to function

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Characterization of the interaction between androgen receptor and a new transcriptional inhibitor, SHP.

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SHP represses transcriptional activity via recruitment of histone deacetylases.

1 reference

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha

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Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

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Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice

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Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho

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Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

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Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

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The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta

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1 reference

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Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene

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The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes a

1 reference

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Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

1 reference

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

1 reference

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Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1

1 reference

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7 January 2021

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Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.

1 reference

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7 January 2021

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Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding

1 reference

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Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

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7 January 2021

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The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7.

1 reference

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Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).

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The Agonist Activity of Tamoxifen Is Inhibited by the Short Heterodimer Partner Orphan Nuclear Receptor in Human Endometrial Cancer Cells

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Enterohepatic bile salt transporters in normal physiology and liver disease

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7 January 2021

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Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner

1 reference

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7 January 2021

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Structure and expression of the orphan nuclear receptor SHP gene

1 reference

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7 January 2021

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Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner

1 reference

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7 January 2021

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inferred from DOI database lookup

Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers

1 reference

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7 January 2021

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The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

1 reference

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7 January 2021

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Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation

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FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade

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Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner

1 reference

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7 January 2021

based on heuristic

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

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7 January 2021

based on heuristic

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Farnesoid X receptor is essential for normal glucose homeostasis

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7 January 2021

based on heuristic

inferred from DOI database lookup

Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP).

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acids reduce SR-BI expression in hepatocytes by a pathway involving FXR/RXR, SHP, and LRH-1.

1 reference

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7 January 2021

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An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors

1 reference

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7 January 2021

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Genetic Variation in the Small Heterodimer Partner Gene and Young-Onset Type 2 Diabetes, Obesity, and Birth Weight in U.K. Subjects

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7 January 2021

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inferred from DOI database lookup

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

1 reference

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7 January 2021

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inferred from DOI database lookup

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

1 reference

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7 January 2021

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Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

1 reference

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7 January 2021

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Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells

1 reference

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7 January 2021

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Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

1 reference

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7 January 2021

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1 reference

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7 January 2021

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Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

1 reference

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7 January 2021

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Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma

1 reference

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7 January 2021

based on heuristic

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Bile acids: natural ligands for an orphan nuclear receptor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes

1 reference

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7 January 2021

based on heuristic

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How many nuclear hormone receptors are there in the human genome?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Novel Receptor Interaction and Repression Domains in the Orphan Receptor SHP

1 reference

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7 January 2021

based on heuristic

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Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

1 reference

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7 January 2021

based on heuristic

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Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of DAX1 and SHP cDNAs and their expression patterns in the Nile tilapia, Oreochromis niloticus

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Redundant pathways for negative feedback regulation of bile acid production

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Resistance of SHP-null mice to bile acid-induced liver damage

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear receptor expression links the circadian clock to metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2961003-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0074-7696(07)61003-1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

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