During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain (Q36639961)

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scientific article published on 28 April 2008

Language	Label	Description	Also known as
English	During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain	scientific article published on 28 April 2008

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Jennifer Thompson

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Astar Winoto

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

28 April 2008

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

205

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1029-1036

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Apoptosis during negative selection of autoreactive thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

A decade of AIRE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Bcl2's flexible loop domain regulates p53 binding and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Positive and negative selection of T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Nuclear hormone receptors in T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Apoptosis signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Chemical genetics: exploring and controlling cellular processes with chemical probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

30 September 2017

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

28 June 2018

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

28 June 2018

Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

TR3/Nur77 in colon cancer cell apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

Gene expression analysis of thymocyte selection in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

Nur77 transcription activity correlates with its apoptotic function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373836

20 September 2018

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://pubmed.ncbi.nlm.nih.gov/18443228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18443228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional analysis of clonal deletion in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18443228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionomycin-induced apoptosis of thymocytes is independent of Nur77 NBRE or NurRE binding, but is accompanied by Nur77 mitochondrial targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/18443228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1 reference

https://pubmed.ncbi.nlm.nih.gov/18443228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20080101

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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