Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors (Q36637356)

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scientific article published on 4 February 2013

Language	Label	Description	Also known as
English	Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors	scientific article published on 4 February 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Xun Shang

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Fillipo Marchioni

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Chris R Evelyn

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Nisha Sipes

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Xuan Zhou

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

William Seibel

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Matthew Wortman

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yi Zheng

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

4 February 2013

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

110

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

3155-3160

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

ZINC: a free tool to discover chemistry for biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

G protein-coupled receptors: novel targets for drug discovery in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Protein-binding assays in biological liquids using microscale thermophoresis

1 reference

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30 September 2017

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

1 reference

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30 September 2017

The druggable genome: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Rho GTPases: biochemistry and biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Making optimal use of empirical energy functions: force-field parameterization in crystal space

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Rho GTPases in cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

The druggable genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Dbl family guanine nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Rho family proteins: coordinating cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

The Dbl family of oncogenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

30 September 2017

Rho family proteins and Ras transformation: the RHOad less traveled gets congested.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581902

20 September 2018

Target analysis: a priori assessment of druggability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23382194

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1212324110

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2013PNAS..110.3155S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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