Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding (Q36649958)

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scientific article published on July 1, 1993

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English	Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding	scientific article published on July 1, 1993

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Europe PubMed Central

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15 August 2017

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding (English)

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15 August 2017

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M. Thali

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17 August 2024

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J. P. Moore

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C. Furman

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M. Charles

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D. D. Ho

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J. Robinson

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J. Sodroski

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publication date

1 July 1993

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https://jvi.asm.org/content/jvi/67/7/3978.full.pdf

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http://jvi.asm.org/cgi/content/abstract/67/7/3978

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7685405/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7685405/?tool=EBI

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17 August 2024

https://europepmc.org/articles/PMC237765

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https://europepmc.org/articles/PMC237765?pdf=render

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https://journals.asm.org/doi/pdf/10.1128/jvi.67.7.3978-3988.1993

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10.1128/JVI.67.7.3978-3988.1993

https://api.crossref.org/works/10.1128/JVI.67.7.3978-3988.1993

17 August 2024

Journal of Virology

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15 August 2017

67

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15 August 2017

7

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15 August 2017

3978-3988

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15 August 2017

Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans

1 reference

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30 September 2017

Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations

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Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

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Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

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30 September 2017

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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30 September 2017

Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1

1 reference

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Purified envelope glycoproteins from human immunodeficiency virus type 1 variants induce individual, type-specific neutralizing antibodies

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30 September 2017

A soluble form of CD4 (T4) protein inhibits AIDS virus infection

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30 September 2017

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1 reference

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30 September 2017

Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody

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30 September 2017

Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule

1 reference

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30 September 2017

Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

30 September 2017

HIV infection is blocked in vitro by recombinant soluble CD4.

1 reference

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30 September 2017

Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein

1 reference

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30 September 2017

Characterization of HIV-1 neutralization escape mutants

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30 September 2017

Generation and characterization of monoclonal antibodies to the putative CD4-binding domain of human immunodeficiency virus type 1 gp120.

1 reference

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30 September 2017

Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

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Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope

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30 September 2017

Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120

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A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus

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Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides

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Persistent infection of chimpanzees with human immunodeficiency virus: serological responses and properties of reisolated viruses.

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Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

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Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein

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Variable and conserved neutralization antigens of human immunodeficiency virus

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Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees.

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30 September 2017

Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees

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Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells

1 reference

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Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

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Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.

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Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

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Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41

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Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160.

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Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans

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Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

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Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

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Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus

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Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain

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A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120.

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Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein

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Transport of membrane proteins to the cell surface

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Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity

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Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons

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Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody

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Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding

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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody

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Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein

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Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization

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Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

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Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody

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Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein

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Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region

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pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

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Soluble CD4 molecules neutralize human immunodeficiency virus type 1.

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Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation

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HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope

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The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?

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Isolate-specific neutralizing antibodies in patients with progressive HIV-1-related disease

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Receptor-mediated activation of immunodeficiency viruses in viral fusion

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Alteration of HIV-1 infectivity and neutralization by a single amino acid replacement in the V3 loop domain

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Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody

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Functional roles of the V3 hypervariable region of HIV-1 gp160 in the processing of gp160 and in the formation of syncytia in CD4+ cells

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A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activity

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Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120

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An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection

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28 June 2018

Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1.

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28 June 2018

Identification of Conserved and Variant Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 by Human Monoclonal Antibodies Produced by EBV-Transformed Cell Lines

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28 June 2018

Epitopes recognized by the neutralizing antibodies of an HIV-1-infected individual

1 reference

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Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation

1 reference

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28 June 2018

Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoprotein

1 reference

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Amino acid residues of the human immunodeficiency virus type I gp120 critical for the binding of rat and human neutralizing antibodies that block the gp120-sCD4 interaction

1 reference

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28 June 2018

Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4-binding site of gp120

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

28 June 2018

Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

28 June 2018

Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gp120.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

28 June 2018

Production of human monoclonal antibodies specific for conformational and linear non-V3 epitopes of gp120.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

28 June 2018

Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

20 September 2018

Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=237765

20 September 2018

Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy between human monoclonal antibodies to HIV extends their effective biologic activity against homologous and divergent strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/7685405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.67.7.3978-3988.1993

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7685405

17 August 2024

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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