Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma. (Q36429595)

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English	Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma.	scientific article

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18 January 2020

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Europe PubMed Central

Alternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma (English)

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18 January 2020

Antonietta R Farina

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18 January 2020

Lucia Cappabianca

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18 January 2020

Andrew Reay Mackay

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18 January 2020

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Antonella Tacconelli

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18 January 2020

Alberto Gulino

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18 January 2020

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1 October 2005

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18 January 2020

Future Oncology

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18 January 2020

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18 January 2020

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18 January 2020

689-698

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18 January 2020

Novel approaches for targeted cancer therapy

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A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

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21 January 2018

Molecular and biochemical characterization of the human trk proto-oncogene

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21 January 2018

Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences

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RET and NTRK1 proto-oncogenes in human diseases.

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Mutational analysis of the TrkA gene in prostate cancer

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Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia

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Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system

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Trk receptor tyrosine kinases: a bridge between cancer and neural development

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Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA.

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21 January 2018

Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells.

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Neural crest development and neuroblastoma: the genetic and biological link

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21 January 2018

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma

1 reference

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21 January 2018

Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21–q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy

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21 January 2018

An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.

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21 January 2018

p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

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21 January 2018

p75NTR--live or let die.

1 reference

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21 January 2018

Neurotrophin signal transduction in the nervous system

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21 January 2018

Trk receptors: mediators of neurotrophin action

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Nerve growth factor binding site on TrkA mapped to a single 24-amino acid leucine-rich motif

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21 January 2018

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor

1 reference

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21 January 2018

TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor

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21 January 2018

NGF stimulation of erk phosphorylation is impaired by a point mutation in the transmembrane domain of trkA receptor

1 reference

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21 January 2018

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

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21 January 2018

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex

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21 January 2018

Nerve growth factor signals via preexisting TrkA receptor oligomers

1 reference

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21 January 2018

Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme

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21 January 2018

Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain

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21 January 2018

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

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21 January 2018

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation

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21 January 2018

TrkA expression in peripheral neuroblastic tumors: prognostic significance and biological relevance

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21 January 2018

Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells

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21 January 2018

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells

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Regulation of Raf-Akt Cross-talk

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Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.

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Hypoxia--a key regulatory factor in tumour growth

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Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

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10.2217/14796694.1.5.689

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16556046%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16556046%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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