The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis (Q36445900)

14 August 2017

The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis (English)

1 reference

14 August 2017

Dong Yun Lee

1 reference

14 August 2017

Bill Sugden

series ordinal

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14 August 2017

language of work or name

English

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publication date

27 November 2007

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14 August 2017

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inferred from page(s)

published in

Blood

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14 August 2017

111

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14 August 2017

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14 August 2017

2280-2289

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describes a project that uses

14 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2234060/fullTextXML

inferred from PubMed Central ID database lookup

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Activity of the LMP1 gene promoter in Epstein-Barr virus-transformed cell lines is modulated by sequence variations in the promoter-proximal CRE site

30 September 2017

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Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells

30 September 2017

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The mammalian unfolded protein response

30 September 2017

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Human cytomegalovirus infection activates and regulates the unfolded protein response

30 September 2017

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Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein

30 September 2017

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

30 September 2017

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

30 September 2017

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

30 September 2017

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High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells

30 September 2017

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Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

30 September 2017

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Epstein-Barr virus provides a survival factor to Burkitt's lymphomas

30 September 2017

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Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle

30 September 2017

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EBNA-1, a bifunctional transcriptional activator

30 September 2017

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The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

30 September 2017

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LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments

30 September 2017

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

30 September 2017

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Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection

30 September 2017

1 reference

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

30 September 2017

1 reference

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

30 September 2017

1 reference

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Plasma cell differentiation requires the transcription factor XBP-1

30 September 2017

1 reference

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

30 September 2017

1 reference

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Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression

30 September 2017

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

30 September 2017

1 reference

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The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation

30 September 2017

1 reference

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

30 September 2017

1 reference

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Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins

30 September 2017

1 reference

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

30 September 2017

1 reference

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CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs

30 September 2017

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

30 September 2017

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Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells

30 September 2017

1 reference

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Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor

30 September 2017

1 reference

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An ATF/CRE element mediates both EBNA2-dependent and EBNA2-independent activation of the Epstein-Barr virus LMP1 gene promoter

30 September 2017

1 reference

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The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB

30 September 2017

1 reference

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Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade

30 September 2017

1 reference

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Cytostatic effect of Epstein-Barr virus latent membrane protein-1 analyzed using tetracycline-regulated expression in B cell lines

30 September 2017

1 reference

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TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

30 September 2017

1 reference

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The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

30 September 2017

1 reference

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The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Response to cAMP levels of the Epstein-Barr virus EBNA2-inducible LMP1 oncogene and EBNA2 inhibition of a PP1-like activity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Latent membrane protein 1 is critical for efficient growth transformation of human B cells by epstein-barr virus

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Latent and lytic cycle promoters of Epstein-Barr virus

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234060

Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042799

12 December 2020

inferred from PubMed ID database lookup

Electroporation: parameters affecting transfer of DNA into mammalian cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042799

12 December 2020

inferred from PubMed ID database lookup

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18042799

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2007-07-100032

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

18042799

1 reference