Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis (Q36330655)

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English	Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

pulmonary fibrosis

1 reference

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John S Munger

15

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Paul H. Weinreb

object named as

Paul H Weinreb

9

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author name string

Khalid Puthawala

1

1 reference

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13 August 2017

Nicos Hadjiangelis

2

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13 August 2017

Steven C Jacoby

3

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13 August 2017

Emmanuel Bayongan

4

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13 August 2017

Zhicheng Zhao

5

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13 August 2017

Zhiwei Yang

6

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13 August 2017

Mary Louise Devitt

7

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13 August 2017

Gerald S Horan

8

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13 August 2017

Matvey E Lukashev

10

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13 August 2017

Shelia M Violette

11

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13 August 2017

Kristen S Grant

12

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13 August 2017

Cristina Colarossi

13

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13 August 2017

Silvia C Formenti

14

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13 August 2017

language of work or name

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publication date

4 October 2007

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13 August 2017

American Journal of Respiratory and Critical Care Medicine

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13 August 2017

177

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13 August 2017

1

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Europe PubMed Central

PMC publication ID

13 August 2017

82-90

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PMC publication ID

13 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2176115/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-beta type II receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Identification of novel p53 target genes in ionizing radiation response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Smad3 as a mediator of the fibrotic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Disorders of lung matrix remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Making sense of latent TGFbeta activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

The integrin alphaVbeta6 binds and activates latent TGFbeta3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

TGF-beta is a critical mediator of acute lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

TGF-beta and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Differential regulation of airway epithelial integrins by growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

30 September 2017

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

29 June 2018

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

29 June 2018

A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

29 June 2018

A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

29 June 2018

Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

22 September 2018

TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

22 September 2018

Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2176115

22 September 2018

Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma TGFβ level in rats after hemithoracic irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced hypoxia may perpetuate late normal tissue injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified method for the analysis of hydroxyproline in biological tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17916808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1164/RCCM.200706-806OC

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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