The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. (Q36116228)

12 August 2017

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. (English)

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12 August 2017

Ian M Love

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12 August 2017

Pedja Sekaric

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12 August 2017

Dingding Shi

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12 August 2017

Steven R Grossman

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12 August 2017

Elliot J Androphy

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12 August 2017

language of work or name

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1 July 2012

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12 August 2017

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inferred from page(s)

published in

Cell Cycle

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12 August 2017

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12 August 2017

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12 August 2017

2458-2466

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3404877/fullTextXML

inferred from PubMed Central ID database lookup

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Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

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A new coactivator function for Zac1's C2H2 zinc finger DNA-binding domain in selectively controlling PCAF activity

2 October 2017

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Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

2 October 2017

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Induction of p21 by p65 in p53 null cells treated with Doxorubicin

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2 October 2017

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FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells

2 October 2017

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2 October 2017

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Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

2 October 2017

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E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

2 October 2017

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Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage

2 October 2017

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

2 October 2017

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HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

2 October 2017

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2 October 2017

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Molecular basis for Gcn5/PCAF histone acetyltransferase selectivity for histone and nonhistone substrates

2 October 2017

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

2 October 2017

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ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

2 October 2017

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

2 October 2017

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Structure of histone acetyltransferases

2 October 2017

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p300/CBP/p53 interaction and regulation of the p53 response

2 October 2017

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Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

2 October 2017

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Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation

2 October 2017

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The PCAF acetylase complex as a potential tumor suppressor

2 October 2017

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PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner

2 October 2017

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Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

2 October 2017

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Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

2 October 2017

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DNA damage activates p53 through a phosphorylation-acetylation cascade

2 October 2017

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Histone-like TAFs within the PCAF histone acetylase complex

2 October 2017

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Histone acetylation and transcriptional regulatory mechanisms

2 October 2017

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

2 October 2017

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Recruitment of p300/CBP in p53-dependent signal pathways

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Binding and modulation of p53 by p300/CBP coactivators

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Synergistic activation of transcription by CBP and p53

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

2 October 2017

1 reference

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RNA synthesis and histone acetylation during the course of gene activation in lymphocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404877

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

2 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCC.20864

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation

21 January 2018

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Crossref

https://api.crossref.org/works/10.4161%2FCC.20864

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

21 January 2018

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Crossref

https://api.crossref.org/works/10.4161%2FCC.20864

Expanded lysine acetylation specificity of Gcn5 in native complexes

21 January 2018

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12 December 2020

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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12 December 2020

NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes

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12 December 2020

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein

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12 December 2020

Identifiers

DOI

10.4161/CC.20864

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22713239

1 reference