Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients. (Q36053982)

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Language	Label	Description	Also known as
English	Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.	scientific article

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1 November 2019

Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients (English)

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1 November 2019

pharmacokinetics

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1

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1 November 2019

4

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1 November 2019

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A A Somogyi

2

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1 November 2019

K R Dyer

3

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1 November 2019

F Bochner

5

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1 November 2019

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1 November 2000

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1 November 2019

British Journal of Clinical Pharmacology

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1 November 2019

50

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1 November 2019

5

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1 November 2019

427-440

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1 November 2019

A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE.

1 reference

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2 October 2017

Population pharmacokinetics of methadone in opiate users: characterization of time-dependent changes

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2 October 2017

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

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2 October 2017

The pharmacokinetics of methadone in healthy subjects and opiate users

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2 October 2017

Comparing methods of measurements

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2 October 2017

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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2 October 2017

Methadone maintenance treatment in opiate dependence: a review.

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2 October 2017

Methadone binding to orosomucoid (alpha 1-acid glycoprotein): determinant of free fraction in plasma

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2 October 2017

Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain

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2 October 2017

Fitting straight lines to experimental data

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2 October 2017

Methadone maintenance: Effect of urinary pH on renal clearance in chronic high and low doses

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2 October 2017

The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone

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11 July 2018

Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two

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11 July 2018

Stereoselective pharmacokinetics of methadone in chronic pain patients

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11 July 2018

Urinary metabolites of DL-methadone in maintenance subjects

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11 July 2018

Influence of plasma pH on quinidine uptake by erythrocytes: estimation of free drug fraction in plasma from blood/and erythrocyte/plasma concentration ratios

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11 July 2018

Methadone concentrations in plasma and their relationship to drug dosage.

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11 July 2018

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

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11 July 2018

Methadone in man: Pharmacokinetic and excretion studies in acute and chronic treatment

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11 July 2018

Stereoselective disposition of methadone in man.

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11 July 2018

Physical dependence liability of drugs of the methadon series and of 6-methyldihydromorphine.

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23 September 2018

Pharmacologic comparison of the optical isomers of methadon.

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23 September 2018

Stereoselective quantification of methadone and its major oxidative metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, in human urine using high-performance liquid chromatography.

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23 September 2018

In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse

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23 September 2018

Ultrafiltration using the Amicon MPS-1 for assessing methadone plasma protein binding

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23 September 2018

Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.

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23 September 2018

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

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23 September 2018

Steady-state pharmacokinetics of methadone in opioid addicts

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23 September 2018

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

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23 September 2018

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

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23 September 2018

The erythromycin breath test predicts the clearance of midazolam

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23 September 2018

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

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23 September 2018

Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics

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21 January 2018

Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships

1 reference

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21 January 2018

Sensitive high-performance liquid chromatographic assay with ultraviolet detection of methadone enantiomers in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy of L-methadone and racemic methadone in substitution treatment for opiate addicts--a double-blind comparison

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantioselective high-performance liquid chromatography determination of methadone enantiomers and its major metabolite in human biological fluids using a new derivatized cyclodextrin-bonded phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of methadone in methadone maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of codeine, morphine, and methadone to human serum proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of liver disease on urinary excretion of methadone and metabolites in maintenance patients: quantitation by direct probe chemical ionization mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of methadone enantiomers in humans using stable isotope-labeled [2H3]-, [2H5]-, and [2H8]Methadone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of urinary pH on the disposition of methadone in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methadone plasma protein binding: alterations in cancer and displacement from alpha 1-acid glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of liver disease on fecal excretion of methadone and its unconjugated metabolites in maintenance patients. Quantitation by direct probe chemical ionization mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered methadone pharmacokinetics in methadone-maintained pregnant women

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chiral analysis of methadone in plasma by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chiral stationary phases in HPLC for the stereoselective determination of methadone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11069437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2125.2000.00272.X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069437%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PMC publication ID

1 reference

Europe PubMed Central

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1 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069437%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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