PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis (Q35410647)

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English	PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis (English)

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PubMed publication ID

8 August 2017

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Johan Auwerx

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Aldons Jake Lusis

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Aldons J Lusis

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Europe PubMed Central

PubMed publication ID

8 August 2017

14

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Karen Reue

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8 August 2017

Nassim Dali-youcef

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Nassim Dali-Youcef

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ORCID Public Data File 2021

Europe PubMed Central

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8 August 2017

author name string

Diana M Shih

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8 August 2017

Janet M Yu

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8 August 2017

Laurent Vergnes

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8 August 2017

Matthew D Champion

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8 August 2017

Asokan Devarajan

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8 August 2017

Peixiang Zhang

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8 August 2017

Lawrence W Castellani

8

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8 August 2017

David N Brindley

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8 August 2017

Carole Jamey

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8 August 2017

Srinivasa T Reddy

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David A Ford

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4 December 2014

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8 August 2017

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8 August 2017

29

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8 August 2017

4

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8 August 2017

1185-1197

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Europe PubMed Central

PubMed publication ID

8 August 2017

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

1 reference

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Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling

1 reference

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

1 reference

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Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

1 reference

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Inflammation in atherosclerosis

1 reference

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ABCC6 localizes to the mitochondria-associated membrane

1 reference

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PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

1 reference

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Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice

1 reference

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Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

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Analysis of cholesteryl esters and diacylglycerols using lithiated adducts and electrospray ionization-tandem mass spectrometry

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Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

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Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

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The three-gene paraoxonase family: Physiologic roles, actions and regulation

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Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele

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An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship

1 reference

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Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice

1 reference

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Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

1 reference

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12 July 2018

One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

12 July 2018

Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

12 July 2018

A common mutation in paraoxonase-2 results in impaired lactonase activity.

1 reference

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MAM: more than just a housekeeper

1 reference

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12 July 2018

How mitochondria produce reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

12 July 2018

Targeting bile-acid signalling for metabolic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

12 July 2018

Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis

1 reference

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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone

1 reference

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Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum

1 reference

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Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.

1 reference

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Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

1 reference

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Cholesterol loading augments oxidative stress in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

1 reference

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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1 reference

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1 reference

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Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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1 reference

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Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

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Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis

1 reference

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The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism

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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

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Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma

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1 reference

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Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

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1 reference

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Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing

1 reference

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1 reference

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1 reference

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Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study

1 reference

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26 September 2018

Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4396607

26 September 2018

Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25477283

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25477283

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.14-260570

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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