Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis (Q35193756)

7 August 2017

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title

Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis (English)

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7 August 2017

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7 August 2017

Robert Goggs

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Stuart D Carter

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Gundula Schulze-Tanzil

series ordinal

object named as

Gundula Schulze-Tanzil

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7 August 2017

Mehdi Shakibaei

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7 August 2017

publication date

1 September 2003

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7 August 2017

published in

The Veterinary Journal

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7 August 2017

volume

166

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7 August 2017

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7 August 2017

page(s)

140-158

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The Bcl-2 protein family: arbiters of cell survival

7 August 2017

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Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee

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The role of nitric oxide in articular cartilage breakdown in osteoarthritis.

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Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro.

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Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

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beta-Integrin-collagen interaction reduces chondrocyte apoptosis

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Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target

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Nucleoside triphosphate pyrophosphatase of rabbit matrix vesicles, a mechanism for the generation of inorganic pyrophosphate in epiphyseal cartilage.

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Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

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7 January 2021

Nitric oxide as a bioregulator of apoptosis

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7 January 2021

Nitric oxide alters chondrocyte function by disrupting cytoskeletal signaling complexes.

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7 January 2021

Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.

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Changes in the chondroitin sulfate-rich region of articular cartilage proteoglycans in experimental osteoarthritis

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7 January 2021

Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear

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7 January 2021

Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins

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7 January 2021

Altered orientation of glycosaminoglycans and cellular changes in the tibial cartilage in the first two weeks of experimental canine osteoarthritis

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7 January 2021

Acceleration of experimental lapine osteoarthritis by calcium pyrophosphate microcrystalline synovitis

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7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

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7 January 2021

The role of the chondrocyte in osteoarthritis

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7 January 2021

Regulated targeting of BAX to mitochondria.

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Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes

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Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis

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7 January 2021

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.

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7 January 2021

Chondrocyte-derived apoptotic bodies and calcification of articular cartilage

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Chondrocyte apoptosis in development, aging and disease

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7 January 2021

The deposition of calcium pyrophosphate and phosphate by matrix vesicles isolated from fetal bovine epiphyseal cartilage

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7 January 2021

The apoptosis cascade--morphological and immunohistochemical methods for its visualization

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7 January 2021

Integrins: versatility, modulation, and signaling in cell adhesion

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7 January 2021

Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells

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7 January 2021

Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-XL

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7 January 2021

ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status

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7 January 2021

IL-1 beta protects human chondrocytes from CD95-induced apoptosis

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7 January 2021

Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes

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7 January 2021

Chondrocyte phenotyping in human osteoarthritis

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7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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7 January 2021

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

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7 January 2021

Effects of shear stress on nitric oxide and matrix protein gene expression in human osteoarthritic chondrocytes in vitro

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7 January 2021

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

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7 January 2021

Anti-Fas-induced apoptosis in chondrocytes reduced by hyaluronan: evidence for CD44 and CD54 (intercellular adhesion molecule 1) invovement

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7 January 2021

Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis

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7 January 2021

Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage.

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7 January 2021

Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro

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7 January 2021

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage

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7 January 2021

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7 January 2021

Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head

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7 January 2021

Interleukin-1 and tumor necrosis factor-alpha increase insulin-like growth factor-binding protein-3 (IGFBP-3) production and IGFBP-3 protease activity in human articular chondrocytes

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7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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7 January 2021

Mitochondria and programmed cell death: back to the future.

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7 January 2021

Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

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7 January 2021

TNF-induced signaling in apoptosis

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7 January 2021

Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts

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7 January 2021

Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes

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7 January 2021

Control of apoptosis by the cellular ATP level

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7 January 2021

Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta

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7 January 2021

Macromolecular substrates for the ICE-like proteases during apoptosis

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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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7 January 2021

Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage

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7 January 2021

Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes

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7 January 2021

Inhibition of chondrogenesis by integrin antibody in vitro.

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Integrin expression and collagen type II implicated in maintenance of chondrocyte shape in monolayer culture: an immunomorphological study

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7 January 2021

Signal transduction by beta1 integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor

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7 January 2021

Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes.

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7 January 2021

A survey of telomerase activity in human cancer

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7 January 2021

Modulation of chondrocyte proteoglycan synthesis by endogeneously produced nitric oxide

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7 January 2021

Nitric oxide in osteoarthritis

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7 January 2021

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

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7 January 2021

Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins

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7 January 2021

Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1

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7 January 2021

Arthritis of the canine stifle joint

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7 January 2021

Inducible nitric oxide expression in equine articular chondrocytes: effects of antiinflammatory compounds

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7 January 2021

The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis

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7 January 2021

Expression of Bcl-2 protein in the epiphyseal plate cartilage and trabecular bone of growing rats

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7 January 2021

Stereological analysis of the epiphyseal growth cartilage in the brachymorphic (bm/bm) mouse, with special reference to the distribution of matrix vesicles

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7 January 2021

Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis

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7 January 2021

Cell death: the significance of apoptosis

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7 January 2021

Synergistic Action of Transforming Growth Factor-β and Insulin-like Growth Factor-I Induces Expression of Type II Collagen and Aggrecan Genes in Adult Human Articular Chondrocytes

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7 January 2021

Apoptosis of Chondrocytes in Transgenic Mice Lacking Collagen II

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7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

7 August 2017

1 reference