ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency (Q34619732)

3 August 2017

title

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency (English)

1 reference

3 August 2017

Liu Cao

1 reference

3 August 2017

Sangsoo Kim

1 reference

3 August 2017

Cuiying Xiao

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3 August 2017

Rui-Hong Wang

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3 August 2017

Xavier Coumoul

1 reference

3 August 2017

Xiaoyan Wang

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3 August 2017

Wen Mei Li

1 reference

3 August 2017

Xiao Ling Xu

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3 August 2017

Joseph A De Soto

1 reference

3 August 2017

Hiroyuki Takai

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3 August 2017

Sabine Mai

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3 August 2017

Stephen J Elledge

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3 August 2017

Noboru Motoyama

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3 August 2017

Chu-Xia Deng

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3 August 2017

language of work or name

English

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publication date

4 May 2006

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3 August 2017

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

2167-2177

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BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

3 August 2017

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Aging and genome maintenance: lessons from the mouse?

7 July 2018

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

7 July 2018

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

7 July 2018

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7 July 2018

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7 July 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

7 July 2018

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

7 July 2018

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BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

7 July 2018

1 reference

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

7 July 2018

1 reference

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7 July 2018

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Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

7 July 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

7 July 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

7 July 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

7 July 2018

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Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

7 July 2018

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

7 July 2018

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Tumors associated with p53 germline mutations: a synopsis of 91 families.

7 July 2018

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Atm-deficient mice: a paradigm of ataxia telangiectasia

7 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 July 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 July 2018

1 reference

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Oncogene-induced senescence as an initial barrier in lymphoma development

7 July 2018

1 reference

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Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

26 October 2018

1 reference

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

26 October 2018

1 reference

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1462967

Thymocyte apoptosis induced by p53-dependent and independent pathways.

26 October 2018

1 reference

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16675955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16675955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601115

1 reference

3 August 2017

1 reference

3 August 2017

1 reference