The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs (Q34523564)

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scholarly article

Language	Label	Description	Also known as
English	The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs	scholarly article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

0 references

James E. Dunford

object named as

James E Dunford

3

0 references

Michael J. Rogers

object named as

Michael J Rogers

7

0 references

object named as

Stefan Knapp

5

0 references

9

object named as

Udo Oppermann

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

author name string

Kathryn L Kavanagh

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Kunde Guo

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Xiaoqiu Wu

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Frank H Ebetino

6

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

R Graham G Russell

8

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

0 references

publication date

9 May 2006

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

103

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

7829-7834

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Likelihood-enhanced fast rotation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Bisphosphonate mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Incorporating target heterogeneity in drug design

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

9 December 2018

https://pubmed.ncbi.nlm.nih.gov/16684881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Bisphosphonates: from the laboratory to the clinic and back again

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Regulation of product chain length by isoprenyl diphosphate synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Human liver prenyltransferase and its characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

The behavior and significance of slow-binding enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Regulation of the mevalonate pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Substrate binding of avian liver prenyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

7 July 2018

Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

Exact analysis of competition ligand binding by displacement isothermal titration calorimetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1472530

27 October 2018

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16684881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.0601643103

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2006PNAS..103.7829K

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

0 references

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