Hsp90 inhibitors as novel cancer chemotherapeutic agents (Q34583912)

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scientific article

Language	Label	Description	Also known as
English	Hsp90 inhibitors as novel cancer chemotherapeutic agents	scientific article

Statements

scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

Hsp90 inhibitors as novel cancer chemotherapeutic agents (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

1 reference

based on heuristic

inferred from title

1

object named as

Len Neckers

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Europe PubMed Central

PubMed publication ID

3 August 2017

publication date

1 January 2002

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Europe PubMed Central

PubMed publication ID

3 August 2017

Trends in Molecular Medicine

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Europe PubMed Central

PubMed publication ID

3 August 2017

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

4 Suppl

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Europe PubMed Central

PubMed publication ID

3 August 2017

S55-61

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Europe PubMed Central

PubMed publication ID

3 August 2017

High constitutive expression of heat shock protein 90α in human acute leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Unusual expression and localization of heat-shock proteins in human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of benzoquinoid ansamycins to p100 correlates with their ability to deplete the erbB2 gene product p185

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hsp90 complex--a super-chaperone machine as a novel drug target

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence-dependent enhancement of paclitaxel toxicity in non-small cell lung cancer by 17-allylamino 17-demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hsp90 as a capacitor for morphological evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2802%2902316-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1471-4914(02)02316-X

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

release_romesjqirzf3dbxwqr7kvbfrje

1 reference

https://api.fatcat.wiki/v0/release/romesjqirzf3dbxwqr7kvbfrje

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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