Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras (Q34468320)

2 August 2017

title

Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras (English)

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2 August 2017

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2 August 2017

Jerrold M Olefsky

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2 August 2017

Soon Young Shin

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2 August 2017

Young Yil Bahk

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2 August 2017

Jesang Ko

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2 August 2017

Il-Yup Chung

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2 August 2017

Young Seek Lee

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2 August 2017

Hermann Eibel

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2 August 2017

Prem M Sharma

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2 August 2017

Young-Ho Kim

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2 August 2017

Bonghee Lee

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2 August 2017

Young Han Lee

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2 August 2017

language of work or name

English

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publication date

2 February 2006

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2 August 2017

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

1093-1103

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The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.

2 August 2017

cites work

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6 July 2018

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6 July 2018

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The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251.

6 July 2018

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RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation

6 July 2018

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6 July 2018

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6 July 2018

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p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

6 July 2018

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6 July 2018

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Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms

6 July 2018

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6 July 2018

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6 July 2018

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Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes

6 July 2018

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The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1.

6 July 2018

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Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

6 July 2018

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

6 July 2018

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Suppression of growth and transformation and induction of apoptosis by EGR-1.

6 July 2018

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Ras effectors and their role in mitogenesis and oncogenesis

6 July 2018

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6 July 2018

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FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Ternary complex factors: growth factor regulated transcriptional activators

6 July 2018

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6 July 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

6 July 2018

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Multiple Ras functions can contribute to mammalian cell transformation

6 July 2018

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Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)

6 July 2018

1 reference

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A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

6 July 2018

1 reference

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ras oncogenes in human cancer: a review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

Functional serum response elements upstream of the growth factor-inducible gene zif268

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

The transcription factor, Egr-1, is rapidly modulated in response to retinoic acid in P19 embryonal carcinoma cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

Gene therapy in the developing world

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600987

p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

Increasing complexity of Ras signaling.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409727

Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16456537

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16456537

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7600987

1 reference

2 August 2017

1 reference

2 August 2017

1 reference