The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling (Q34301702)

1 August 2017

title

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling (English)

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1 August 2017

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GOA release 2020-03-11

Fused Dmel_CG6551

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GOA release 2020-03-11

Manuel Ascano

1 reference

1 August 2017

Kent E Nybakken

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1 August 2017

Janek Sosinski

series ordinal

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1 August 2017

Melanie A Stegman

series ordinal

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1 August 2017

David J Robbins

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 March 2002

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Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

1555-1566

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The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

1 August 2017

cites work

1 reference

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Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

6 July 2018

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Gli regulation by the opposing activities of fused and suppressor of fused

6 July 2018

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Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

6 July 2018

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Ci: a complex transducer of the hedgehog signal

6 July 2018

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Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

6 July 2018

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Formation of morphogen gradients in the Drosophila wing

6 July 2018

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6 July 2018

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Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway

6 July 2018

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Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

6 July 2018

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Catching a Gli-mpse of Hedgehog

6 July 2018

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

6 July 2018

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Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors

6 July 2018

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Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

6 July 2018

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Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast

6 July 2018

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The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs.

6 July 2018

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Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila

6 July 2018

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Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients

6 July 2018

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

6 July 2018

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

6 July 2018

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Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.

6 July 2018

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Phosphorylation of the fused protein kinase in response to signaling from hedgehog

6 July 2018

1 reference

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gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

6 July 2018

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Drosophila hedgehog acts as a morphogen in cellular patterning.

6 July 2018

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Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.

6 July 2018

1 reference

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Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

6 July 2018

1 reference

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

6 July 2018

1 reference

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Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster.

6 July 2018

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Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development

6 July 2018

1 reference

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Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein

6 July 2018

1 reference

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Three distinct roles for the engrailed gene in Drosophila wing development.

6 July 2018

1 reference

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Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis

6 July 2018

1 reference

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The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment

6 July 2018

1 reference

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Mutations affecting segment number and polarity in Drosophila

6 July 2018

1 reference

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Genetic Transformation of Drosophila with Transposable Element Vectors

6 July 2018

1 reference

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Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

6 July 2018

1 reference

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Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Repression of ci-D in posterior compartments of Drosophila by engrailed

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Pattern formation in the wing veins of the fused mutant (Drosophila melanogaster)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Genetic dissection of the Drosophila Cubitus interruptus signaling complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

A gain-of-function mutant of patched dissects different responses to the hedgehog gradient.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Identification of a tetrameric hedgehog signaling complex

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Visualization of gene expression in living adult Drosophila.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

dpp induces mesodermal gene expression in Drosophila.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134684

The hedgehog gene family in Drosophila and vertebrate development

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11839821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic analysis of hedgehog signalling in the Drosophila embryo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11839821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.22.5.1555-1566.2002

1 reference

1 August 2017

1 reference

1 August 2017

1 reference