HER2/neu: mechanisms of dimerization/oligomerization (Q34130541)

31 July 2017

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title

HER2/neu: mechanisms of dimerization/oligomerization (English)

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31 July 2017

Brennan PJ

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31 July 2017

Kumagai T

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31 July 2017

Berezov A

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31 July 2017

Murali R

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31 July 2017

Greene MI

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31 July 2017

language of work or name

English

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publication date

1 December 2000

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

6093-6101

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The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

The neu oncogene encodes an epidermal growth factor receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Conformation of the transmembrane domain of the c-erbB-2 oncogene-encoded protein in its monomeric and dimeric states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p185 protein with its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

A unified model of c-erbB receptor homo- and heterodimerisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Two EGF molecules contribute additively to stabilization of the EGFR dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

NIH/3T3 cells transformed with the activated erbB-2 oncogene can be phenotypically reverted by a kinase deficient, dominant negative erbB-2 variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Single-molecule imaging of EGFR signalling on the surface of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Bivalence of EGF-like ligands drives the ErbB signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Direct visualization and quantitative analysis of epidermal growth factor-induced receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Neu receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Conformational energy analysis of the leucine repeat regions of C/EBP, GCN4, and the proteins of the myc, jun, and fos oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

High-yield trapping of EGF-induced receptor dimers by chemical cross-linking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Secondary dimerization between members of the epidermal growth factor receptor family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Binding specificities and affinities of egf domains for ErbB receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203967

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203967

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Dimensions Publication ID

31 July 2017

1012699907

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1 reference