Centrosome aberrations: cause or consequence of cancer progression? (Q34157650)

31 July 2017

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title

Centrosome aberrations: cause or consequence of cancer progression? (English)

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31 July 2017

Erich A Nigg

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language of work or name

English

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publication date

1 November 2002

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31 July 2017

published in

Nature Reviews Cancer

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

815-825

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Centrosome composition and microtubule anchoring mechanisms

31 July 2017

cites work

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Re-evaluating centrosome function

31 March 2020

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Integration of the centrosome in cell cycle control, stress response and signal transduction pathways

31 March 2020

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"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle

31 March 2020

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31 March 2020

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Requirement of a centrosomal activity for cell cycle progression through G1 into S phase

31 March 2020

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Four-dimensional control of the cell cycle

31 March 2020

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The centrosome in vertebrates: more than a microtubule-organizing center

31 March 2020

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DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos

31 March 2020

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Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity

31 March 2020

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Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations

31 March 2020

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Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex

31 March 2020

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The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility

31 March 2020

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Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

31 March 2020

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The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.

31 March 2020

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The coordination of centrosome reproduction with nuclear events during the cell cycle

31 March 2020

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

31 March 2020

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

31 March 2020

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Cyclin-dependent kinase control of centrosome duplication

31 March 2020

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

31 March 2020

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Altered centrosome structure is associated with abnormal mitoses in human breast tumors

31 March 2020

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Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

31 March 2020

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Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts

31 March 2020

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Centrosome hyperamplification in head and neck squamous cell carcinoma: a potential phenotypic marker of tumor aggressiveness

31 March 2020

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Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

31 March 2020

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Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

31 March 2020

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Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions

31 March 2020

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Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

31 March 2020

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Centrosome amplification drives chromosomal instability in breast tumor development

31 March 2020

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The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

31 March 2020

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Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells

31 March 2020

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Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization

31 March 2020

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Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation

31 March 2020

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Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes

31 March 2020

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Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice

31 March 2020

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Managing the centrosome numbers game: from chaos to stability in cancer cell division

31 March 2020

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Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells

31 March 2020

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

31 March 2020

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Overexpression of cyclin A in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction

31 March 2020

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The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

31 March 2020

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17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

31 March 2020

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Abnormal centrosome amplification in the absence of p53.

31 March 2020

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Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.

31 March 2020

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Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

31 March 2020

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

31 March 2020

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Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

31 March 2020

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p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.

31 March 2020

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

31 March 2020

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

31 March 2020

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Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells

31 March 2020

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The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

31 March 2020

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Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation.

31 March 2020

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The role of the centrosome in the development of malignant tumors

31 March 2020

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The mitotic machinery as a source of genetic instability in cancer

31 March 2020

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Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

31 March 2020

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Asymmetric cell division during animal development

31 March 2020

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Polarity and nucleation of microtubules in polarized epithelial cells

31 March 2020

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Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells

31 March 2020

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The mitotic spindle: a self-made machine

31 March 2020

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Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression

31 March 2020

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Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells

31 March 2020

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Mitosis in a cell with multiple centrioles

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Chromosome segregation and cancer: cutting through the mystery

31 March 2020

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A possible role for centrosome overduplication in radiation-induced cell death

31 March 2020

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Genomic instability in Gadd45a-deficient mice

31 March 2020

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Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest

31 March 2020

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

31 March 2020

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Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency

31 March 2020

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

31 March 2020

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

31 March 2020

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Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

31 March 2020

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Genome changes and gene expression in human solid tumors

31 March 2020

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Genetic instabilities in human cancers

31 March 2020

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How many mutations in a cancer?

31 March 2020

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Cell cycle control and cancer

31 March 2020

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Mitotic kinases as regulators of cell division and its checkpoints

31 March 2020

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Structural and chemical characterization of isolated centrosomes

31 March 2020

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Centrosome organization and centriole architecture: their sensitivity to divalent cations

31 March 2020

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Polarities of the centriolar structure: morphogenetic consequences

31 March 2020

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A structural scaffolding of intermediate filaments in health and disease

31 March 2020

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Centrosome-dependent exit of cytokinesis in animal cells

31 March 2020

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The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

31 March 2020

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Mode of centriole duplication and distribution

31 March 2020

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Centrosome reproduction in Xenopus lysates

31 March 2020

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Centrosome reproduction in vitro: mammalian centrosomes in Xenopus lysates

31 March 2020

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De novo formation of centrosomes in vertebrate cells arrested during S phase

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC924

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Dimensions Publication ID

31 July 2017

1007068023

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