Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography (Q34067336)

30 July 2017

title

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography (English)

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positron emission tomography

30 July 2017

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Hendrikse NH

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30 July 2017

Schinkel AH

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30 July 2017

de Vries EG

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30 July 2017

Fluks E

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30 July 2017

Van der Graaf WT

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30 July 2017

Willemsen AT

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30 July 2017

Vaalburg W

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30 July 2017

Franssen EJ

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30 July 2017

language of work or name

English

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publication date

1 August 1998

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British Journal of Pharmacology

30 July 2017

published in

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30 July 2017

volume

124

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30 July 2017

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30 July 2017

page(s)

1413-1418

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Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1

30 July 2017

cites work

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Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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Biochemistry of multidrug resistance mediated by the multidrug transporter

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A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

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Interaction of drugs with P-glycoprotein in brain capillaries

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7 January 2021

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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7 January 2021

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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7 January 2021

A method to determine the ability of drugs to diffuse through the blood-brain barrier

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Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

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7 January 2021

Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells

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7 January 2021

Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells

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7 January 2021

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

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Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy

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Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy

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7 January 2021

Identifiers

DOI

10.1038/SJ.BJP.0701979

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30 July 2017

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30 July 2017

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