Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita (Q33378030)

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English	Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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haploinsufficiency

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dyskeratosis congenita

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based on heuristic

inferred from title

author name string

Hua He

1

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Europe PubMed Central

PubMed publication ID

26 July 2017

Yang Wang

2

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Europe PubMed Central

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26 July 2017

Xiaolan Guo

3

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26 July 2017

Sonal Ramchandani

4

1 reference

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26 July 2017

Jin Ma

5

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Europe PubMed Central

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26 July 2017

Mei-Feng Shen

6

1 reference

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26 July 2017

Dennis A Garcia

7

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Yibin Deng

8

1 reference

Europe PubMed Central

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26 July 2017

Asha S Multani

9

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Mingjian James You

10

1 reference

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26 July 2017

Sandy Chang

11

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26 July 2017

language of work or name

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publication date

20 October 2008

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Europe PubMed Central

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26 July 2017

Molecular and Cellular Biology

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Europe PubMed Central

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26 July 2017

29

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26 July 2017

1

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26 July 2017

229-240

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26 July 2017

How shelterin protects mammalian telomeres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Engineered telomere degradation models dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Telomere dysfunction and tumour suppression: the senescence connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Pot1 and cell cycle progression cooperate in telomere length regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

The POT1-TPP1 telomere complex is a telomerase processivity factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Short telomeres, even in the presence of telomerase, limit tissue renewal capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Switching human telomerase on and off with hPOT1 protein in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

POT1 as a terminal transducer of TRF1 telomere length control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Pot1, the putative telomere end-binding protein in fission yeast and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Dyskeratosis congenita in all its forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

21 June 2018

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2612488

31 October 2018

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between aplastic anaemia and mutations in telomerase RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01400-08

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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