The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells (Q28343482)

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scientific article

Language	Label	Description	Also known as
English	The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells	scientific article

Statements

scholarly article

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The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells (English)

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1 reference

based on heuristic

inferred from title

author name string

O Porzio

1

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M Federici

2

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M L Hribal

3

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D Lauro

4

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D Accili

5

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R Lauro

6

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P Borboni

7

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G Sesti

8

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language of work or name

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publication date

August 1999

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Journal of Clinical Investigation

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104

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3

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357-64

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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

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Role of IRS-2 in insulin and cytokine signalling

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

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Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling

1 reference

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

1 reference

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A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1 reference

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Insulin action and the insulin signaling network

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Mapping genes in diabetes. Genetic epidemiological perspective

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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

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Mutations in the insulin receptor gene

1 reference

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The insulin signalling system and the IRS proteins

1 reference

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

1 reference

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IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

1 reference

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Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells

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Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

1 reference

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Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells

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Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

1 reference

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Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

1 reference

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Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.

1 reference

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Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1 reference

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Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10430617

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based on heuristic

inferred from PubMed ID database lookup

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms

1 reference

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inferred from PubMed ID database lookup

UKPDS 19: Heterogeneity in NIDDM: separate contributions of IRS-1 and b3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations

1 reference

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inferred from PubMed ID database lookup

Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets

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Identifiers

10.1172/JCI5870

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