Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine (Q27666091)

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scientific article published on November 28, 2010

Language	Label	Description	Also known as
English	Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine	scientific article published on November 28, 2010

Statements

scholarly article

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Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine (English)

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author name string

Margit Hagel

1

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Deqiang Niu

2

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Thia St Martin

3

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Lixin Qiao

5

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Hugues Bernard

6

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Zhendong Zhu

8

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Prasoon Chaturvedi

10

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Mariana Nacht

11

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Juswinder Singh

14

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Michael P. Sheets

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

Russell M. Karp

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

Matthew T. Labenski

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

William F. Westlin

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

Russell C. Petter

13

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21113170

4 September 2024

publication date

January 2011

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28 November 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21113170

4 September 2024

full work available at URL

http://www.nature.com/articles/nchembio.492.pdf

1 reference

10.1038/NCHEMBIO.492

https://api.crossref.org/works/10.1038/NCHEMBIO.492

4 September 2024

http://www.nature.com/articles/nchembio.492

1 reference

10.1038/NCHEMBIO.492

https://api.crossref.org/works/10.1038/NCHEMBIO.492

4 September 2024

Nature Chemical Biology

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7

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1

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22-4

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Drugs in development for hepatitis C.

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Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture

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Antiviral resistance and specifically targeted therapy for HCV (STAT-C).

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Targeting proteases: successes, failures and future prospects

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Differential Requirements of NS4A for Internal NS3 Cleavage and Polyprotein Processing of Hepatitis C Virus

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Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease

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Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins

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Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection

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Human and mouse proteases: a comparative genomic approach

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Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease

1 reference

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Mechanistic basis of enzyme-targeted drugs

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

1 reference

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Identifiers

10.1038/NCHEMBIO.492

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PubMed publication ID

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ResearchGate publication ID

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