A small molecule that binds Hedgehog and blocks its signaling in human cells (Q24646445)

object named as

Stuart L Schreiber

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author name string

Benjamin Z Stanton

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Lee F Peng

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Nicole Maloof

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Kazuo Nakai

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Xiang Wang

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Jay L Duffner

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Kennedy M Taveras

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Joel M Hyman

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Sam W Lee

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Angela N Koehler

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Julia L Fox

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Anna Mandinova

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

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language of work or name

English

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publication date

March 2009

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published in

Nature Chemical Biology

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volume

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issue

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page(s)

154-6

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Small molecule modulation of Smoothened activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Generating Diverse Skeletons of Small Molecules Combinatorially

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Hedgehog signaling in animal development: paradigms and principles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Mutations affecting segment number and polarity in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Basal cell carcinomas: attack of the hedgehog

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

A robust small-molecule microarray platform for screening cell lysates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

A role for chemistry in stem cell biology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2770933

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.142

Targeting the Hedgehog pathway in cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19151731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sweet surrender to chemical genetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19151731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.142

1 reference

Dimensions Publication ID

1049513174

0 references

1 reference

1 reference

PubMed publication ID

19151731

1 reference