Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ (Q24329243)

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scientific article published on September 1, 1995

Language	Label	Description	Also known as
English	Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ	scientific article published on September 1, 1995

Statements

scholarly article

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Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta (English)

0 references

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ (English)

1 reference

10.1128/MCB.15.9.4971

https://api.crossref.org/works/10.1128/MCB.15.9.4971

17 July 2024

0 references

estrogen receptor 1

1 reference

GOA release 2020-03-11

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

developmental gene expression regulation

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

I-kappa B proteins

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

author name string

B. Stein

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

M. X. Yang

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

language of work or name

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publication date

September 1995

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full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230744

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

http://mcb.asm.org/cgi/content/abstract/15/9/4971

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7651415/pdf/?tool=EBI

Portable Document Format

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7651415/?tool=EBI

online access status

content deliverer

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

https://europepmc.org/articles/PMC230744

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

https://europepmc.org/articles/PMC230744?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7651415

17 July 2024

https://journals.asm.org/doi/pdf/10.1128/MCB.15.9.4971

1 reference

10.1128/MCB.15.9.4971

https://api.crossref.org/works/10.1128/MCB.15.9.4971

17 July 2024

https://www.tandfonline.com/doi/pdf/10.1128/MCB.15.9.4971

1 reference

10.1128/MCB.15.9.4971

https://api.crossref.org/works/10.1128/MCB.15.9.4971

17 July 2024

Molecular and Cellular Biology

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15

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9

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4971-9

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Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

1 reference

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Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence

1 reference

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19 March 2017

Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription

1 reference

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Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man

1 reference

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Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids

1 reference

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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

1 reference

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Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B

1 reference

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19 March 2017

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

1 reference

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19 March 2017

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

1 reference

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19 March 2017

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

1 reference

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7 April 2017

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

7 April 2017

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

That oestrogen replacement for osteoporosis prevention should no longer be a bone of contention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

1 reference

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27 September 2017

Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B.

1 reference

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27 September 2017

17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism

1 reference

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27 September 2017

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Interaction of proteins with transcriptionally active estrogen receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230744

27 September 2017

Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha

1 reference

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27 September 2017

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

1 reference

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Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1 reference

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Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts

1 reference

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Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone

1 reference

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Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor

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Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity

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The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblastsin Vitro*

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Risks and benefits of replacement estrogen

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Future prospects for hormone replacement therapy

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HRT and osteoporosis

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Estrogen binding and estrogenic responses in normal human osteoblast-like cells

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Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

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Characterisation of functional inhibition of the glucocorticoid receptor by Fos/Jun

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Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1

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Long-term estrogen replacement therapy prevents bone loss and fractures

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A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA

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Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice

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12 December 2020

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Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

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Production of tumor necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones

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Interleukin-6: an osteotropic factor?

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Increased osteoclast development after estrogen loss: mediation by interleukin-6

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Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

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Functional domains of the human estrogen receptor

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Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells

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Evidence of estrogen receptors in normal human osteoblast-like cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7651415

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based on heuristic

inferred from PubMed ID database lookup

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7651415

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based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 inhibits bone formation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7651415

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based on heuristic

inferred from PubMed ID database lookup

Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal

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https://pubmed.ncbi.nlm.nih.gov/7651415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/MCB.15.9.4971

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