Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size (Q24314330)

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25 January 2020

title

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size (English)

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25 January 2020

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transforming growth factor beta 1

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negative regulation of cell differentiation

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Myostatin

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25 January 2020

author name string

Anne Ulrike Trendelenburg

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25 January 2020

Angelika Meyer

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25 January 2020

Daisy Rohner

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25 January 2020

Joseph Boyle

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25 January 2020

David J Glass

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language of work or name

English

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publication date

8 April 2009

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American Journal of Physiology - Cell Physiology

25 January 2020

published in

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volume

296

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issue

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page(s)

C1258-70

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Curcumin prevents lipopolysaccharide-induced atrogin-1/MAFbx upregulation and muscle mass loss

25 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Skeletal muscle hypertrophy and atrophy signaling pathways

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

IGF-1 induces human myotube hypertrophy by increasing cell recruitment

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Molecular mechanisms modulating muscle mass

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Inhibition of autocrine secretion of myostatin enhances terminal differentiation in human rhabdomyosarcoma cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Double muscling in cattle due to mutations in the myostatin gene

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Myostatin inhibits myoblast differentiation by down-regulating MyoD expression.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Conditional activation of MET in differentiated skeletal muscle induces atrophy.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Mutations in myostatin (GDF8) in Double-Muscled Belgian Blue and Piedmontese Cattle

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Molecular biomarkers monitoring human skeletal muscle fibres and microvasculature following long-term bed rest with and without countermeasures.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Identification of ubiquitin ligases required for skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Induction of cachexia in mice by systemically administered myostatin.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Smad2 and 3 transcription factors control muscle mass in adulthood.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

IFN-gamma does not mimic the catabolic effects of TNF-alpha

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Myostatin regulates cardiomyocyte growth through modulation of Akt signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Differential response to exogenous and endogenous myostatin in myoblasts suggests that myostatin acts as an autocrine factor in vivo

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Ectopic expression of myostatin induces atrophy of adult skeletal muscle by decreasing muscle gene expression.

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00105.2009

7 January 2021

10.1152/AJPCELL.00105.2009

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25 January 2020

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19357233%20AND%20SRC:MED&resulttype=core&format=json