Crystal structure of human cytochrome P450 2D6 (Q24298673)

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Language	Label	Description	Also known as
English	Crystal structure of human cytochrome P450 2D6	scientific article

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scholarly article

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Crystal structure of human cytochrome P450 2D6 (English)

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crystal structure

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cytochrome P450 family 2 subfamily D member 6

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GOA release 2020-03-11

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GOA release 2020-03-11

8

object named as

Mike G Tennant

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author name string

Paul Rowland

1

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Frank E Blaney

2

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Martin G Smyth

3

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Jo J Jones

4

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Vaughan R Leydon

5

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Amanda K Oxbrow

6

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Ceri J Lewis

7

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Sandeep Modi

9

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Drake S Eggleston

10

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Richard J Chenery

11

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Angela M Bridges

12

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language of work or name

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publication date

17 March 2006

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Journal of Biological Chemistry

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281

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11

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7614-22

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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Identification of the primary gene defect at the cytochrome P450 CYP2D locus

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Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisal

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The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms

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Cytochrome p450 in silico: an integrative modeling approach.

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A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

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Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure

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Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

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Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

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Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

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Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution.

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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Hidden Markov models

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ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

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Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

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Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

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Microsomal P450 2C3 is expressed as a soluble dimer in Escherichia coli following modification of its N-terminus

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Processing of X-ray diffraction data collected in oscillation mode

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The CCP4 suite: programs for protein crystallography

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Likelihood-enhanced fast rotation functions

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Coot: model-building tools for molecular graphics

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Refinement of macromolecular structures by the maximum-likelihood method

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

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PROCHECK: a program to check the stereochemical quality of protein structures

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CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

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A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

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Purification and characterization of recombinant-expressed cytochrome P450 2C3 from Escherichia coli: 2C3 encodes the 6 beta-hydroxylase deficient form of P450 3b.

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Use of non-crystallographic symmetry in protein structure refinement

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Detection, delineation, measurement and display of cavities in macromolecular structures

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Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

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The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

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Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

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Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

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Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity

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Catalytic specificity of CYP2D isoforms in rat and human

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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

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Deletion of a conserved tetrapeptide, PPGP, in P450 2C2 results in loss of enzymatic activity without a change in its cellular location

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Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

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inferred from DOI database lookup

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4

1 reference

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based on heuristic

inferred from DOI database lookup

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

1 reference

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based on heuristic

inferred from DOI database lookup

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

1 reference

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inferred from DOI database lookup

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M511232200

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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