Inhibin beta A subunit (Q21107468)

InterPro Release 65.0

http://www.ebi.ac.uk/interpro/protein/P08476

1 reference

11 May 2017

1 reference

11 May 2017

transforming growth factor beta receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

1 reference

26 September 2017

signaling receptor binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

hormone activity

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

identical protein binding

1 reference

26 September 2017

Activin B: precursor sequences, genomic structure and in vitro activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

growth factor activity

Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

inhibin binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cytokine activity

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

protein heterodimerization activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

type II activin receptor binding

1 reference

26 September 2017

Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

peptide hormone binding

1 reference

26 September 2017

The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

protein binding

4 references

26 September 2017

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

Differential Binding and Neutralization of Activins A and B by Follistatin and Follistatin Like-3 (FSTL-3/FSRP/FLRG)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

Activin B: precursor sequences, genomic structure and in vitro activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

Structural basis for the inhibition of activin signalling by follistatin.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cell component

activin A complex

1 reference

26 September 2017

Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

perinuclear region of cytoplasm

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

26 September 2017

Expression of activin/inhibin receptor and binding protein genes and regulation of activin/inhibin peptide secretion in human adrenocortical cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

extracellular space

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of cell population proliferation

biological process

1 reference

26 September 2017

Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

endodermal cell differentiation

1 reference

26 September 2017

HEB and E2A function as SMAD/FOXH1 cofactors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of follicle-stimulating hormone secretion

1 reference

26 September 2017

Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

GABAergic neuron differentiation

1 reference

26 September 2017

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cell-cell signaling

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

progesterone secretion

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

mesodermal cell differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of macrophage differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

odontogenesis

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of interferon-gamma production

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

hair follicle development

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

regulation of transcription by RNA polymerase II

1 reference

26 September 2017

Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of phosphorylation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

SMAD protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

1 reference

26 September 2017

extrinsic apoptotic signaling pathway

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

regulation of cell cycle

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of follicle-stimulating hormone secretion

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cell surface receptor signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

26 September 2017

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

nervous system development

1 reference

26 September 2017

A novel role of activin in inflammation and repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of gene expression

1 reference

26 September 2017

Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

26 September 2017

Activin A induces apoptotic cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cellular response to cholesterol

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

mesoderm formation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

activin receptor signaling pathway

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of B cell differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

ovarian follicle development

striatal medium spiny neuron differentiation

1 reference

26 September 2017

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of protein metabolic process

1 reference

26 September 2017

HEB and E2A function as SMAD/FOXH1 cofactors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of transcription, DNA-templated

hemoglobin biosynthetic process

1 reference

26 September 2017

Effect of activin A on globin gene expression in purified human erythroid progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

roof of mouth development

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

positive regulation of erythrocyte differentiation

1 reference

26 September 2017

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cellular response to follicle-stimulating hormone stimulus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

regulation of MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

1 reference

26 September 2017

cell development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

1 reference

26 September 2017

positive regulation of transcription by RNA polymerase II

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of cell cycle

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

G1 phase

1 reference

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

negative regulation of cell growth

2 references

26 September 2017

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

26 September 2017

The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

response to drug

1 reference

26 September 2017

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

cell differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

defense response

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

erythrocyte differentiation

1 reference

26 September 2017

Effect of activin A on globin gene expression in purified human erythroid progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

male gonad development

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

regulation of follicle-stimulating hormone secretion

1 reference

26 September 2017

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08476&geneProductId=UniProtKB:P08476

Identifiers

1 reference

13 May 2017

1 reference

13 May 2017

1 reference

13 May 2017

1 reference

13 May 2017

1 reference

11 May 2017

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016