Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells (Q89051430)

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30 March 2020

title

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29886047%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

Akos A Gerencser

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publication date

8 June 2018

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30 March 2020

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30 March 2020

volume

1859

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issue

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30 March 2020

page(s)

817-828

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Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests

30 March 2020

cites work

1 reference

12 December 2020

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion

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Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans

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Interrelationship of islet metabolism, adenosine triphosphate content and insulin release

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Early insulin responses to glucose and to tolbutamide in maturity-onset diabetes

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Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release. Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets

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Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)

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12 December 2020

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

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Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells

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Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells

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12 December 2020

Decreased insulin action and insulin secretion predict the development of impaired glucose tolerance

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Regulation analysis of energy metabolism

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Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

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Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase

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Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria

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Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets

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Internal regulation of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes

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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

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Glutamate is not a messenger in insulin secretion

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

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Glucose-induced oscillations in cytoplasmic free Ca2+ concentration precede oscillations in mitochondrial membrane potential in the pancreatic beta-cell.

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Phasic insulin release and metabolic regulation in type 2 diabetes.

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12 December 2020

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

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Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis

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12 December 2020

Visualizing superoxide production in normal and diabetic rat islets of Langerhans

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12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

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Five stages of evolving beta-cell dysfunction during progression to diabetes

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Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

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12 December 2020

Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin

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12 December 2020

Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.

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12 December 2020

Stronger control of ATP/ADP by proton leak in pancreatic beta-cells than skeletal muscle mitochondria

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12 December 2020

Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells

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12 December 2020

Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.

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12 December 2020

The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

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12 December 2020

Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets

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12 December 2020

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

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12 December 2020

Mitochondrial GTP regulates glucose-stimulated insulin secretion

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12 December 2020

Glucose-stimulated increment in oxygen consumption rate as a standardized test of human islet quality.

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12 December 2020

Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats

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12 December 2020

Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential

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12 December 2020

A novel method for the detection of viable human pancreatic beta cells by flow cytometry using fluorophores that selectively detect labile zinc, mitochondrial membrane potential and protein thiols.

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12 December 2020

Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

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12 December 2020

Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation

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12 December 2020

Regulation of insulin secretion: a matter of phase control and amplitude modulation

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12 December 2020

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

1 reference

12 December 2020

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

1 reference

12 December 2020

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.

1 reference

12 December 2020

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes

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12 December 2020

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

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12 December 2020

A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.

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12 December 2020

Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets

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12 December 2020

Assessing mitochondrial dysfunction in cells.

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12 December 2020

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

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12 December 2020

Abnormal mitochondrial function impairs calcium influx in diabetic mouse pancreatic beta cells

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12 December 2020

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria

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12 December 2020

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

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12 December 2020

Prediabetes: a high-risk state for diabetes development.

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12 December 2020

When less is more: the forbidden fruits of gene repression in the adult β-cell

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12 December 2020

Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.

1 reference

12 December 2020

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

1 reference

12 December 2020

Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism.

1 reference

12 December 2020

Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets.

1 reference

12 December 2020

Metabolic signaling in fuel-induced insulin secretion

1 reference

12 December 2020

Minor role of mitochondrial respiration for fatty-acid induced insulin secretion

1 reference

12 December 2020

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

1 reference

12 December 2020

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells

1 reference

12 December 2020

α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion

1 reference

12 December 2020

Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.

1 reference

12 December 2020

Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

1 reference

12 December 2020

Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic β-cell insulin secretion

1 reference

12 December 2020

Bioenergetic Analysis of Single Pancreatic β-Cells Indicates an Impaired Metabolic Signature in Type 2 Diabetic Subjects

1 reference

12 December 2020

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

1 reference

12 December 2020

Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

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12 December 2020

Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells

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12 December 2020

The Pancreatic β-Cell: A Bioenergetic Perspective

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12 December 2020

Positive Feedback Amplifies the Response of Mitochondrial Membrane Potential to Glucose Concentration in Clonal Pancreatic Beta Cells

1 reference

12 December 2020

Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.

1 reference

12 December 2020

A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells.

1 reference

12 December 2020

The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism

1 reference

12 December 2020

The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance

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12 December 2020

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions.

1 reference

12 December 2020

Transcribing β-cell mitochondria in health and disease

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12 December 2020

Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model.

1 reference

12 December 2020

Control of pancreatic β-cell bioenergetics.

1 reference

12 December 2020

10.1016/J.BBABIO.2018.06.006

Identifiers

DOI

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30 March 2020

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30 March 2020

PubMed publication ID

29886047

1 reference

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