Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications (Q88090581)

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scientific article published on 11 March 2018

Language	Label	Description	Also known as
English	Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications	scientific article published on 11 March 2018

Statements

scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

pharmacokinetics

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

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20 March 2020

author name string

Stefan K Plontke

2

1 reference

Europe PubMed Central

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20 March 2020

publication date

11 March 2018

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Hearing Research

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

368

1 reference

Europe PubMed Central

PMC publication ID

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20 March 2020

28-40

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Macromolecular transport by the middle ear and its lymphatic system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Menière's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone lining cells of the mammalian cochlea

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratympanic gentamicin instillation as treatment of unilateral Menière's disease: update of an ongoing study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratympanic gentamicin therapy for Menière's disease: preliminary comparison of two regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone inner ear perfusion for the treatment of Meniere's disease: a prospective, randomized, double-blind, crossover trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug absorption using multivariate statistics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical aspects of round window membrane permeability under normal and pathological conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steroidogenic Enzyme Expression in the Rat Cochlea

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation therapy for the relief of Ménière's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-Term Evaluation of the Effect of Intracochlear Steroid Deposition on Electrode Impedance in Cochlear Implant Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transtympanic injection of anesthetics for the treatment of Méniére's syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local inner-ear drug delivery and pharmacokinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes of postoperative impedances in cochlear implant patients: the short-term effects of modified electrode surfaces and intracochlear corticosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transsynaptic delivery of nanoparticles to the central auditory nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone concentration gradients along scala tympani after application to the round window membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localized cell and drug delivery for auditory prostheses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of the round window membrane is influenced by the composition of applied drug solutions and by common surgical procedures

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Issues, indications, and controversies regarding intratympanic steroid perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inner ear drug delivery for auditory applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of local drug delivery to the inner ear.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent sustained release of dexamethasone in inner ear cochlear fluids using a novel local delivery approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticosteroid-releasing cochlear implant: a novel hybrid of biomaterial and drug delivery system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of inner ear sustained release following intratympanic administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of reciprocating drug delivery to the inner ear

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nanoparticle-based delivery for the treatment of inner ear disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local drug delivery to the inner ear using biodegradable materials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticosteroid therapy for hearing and balance disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual origin of the epithelium of the mammalian middle ear.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tympanotomy with sealing of the round window as surgical salvage option in sudden idiopathic sensorineural hearing loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OTO-201: nonclinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human transporter database: comprehensive knowledge and discovery tools in the human transporter genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of intracochlear drug delivery devices in the management of inner ear disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treating hearing disorders with cell and gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of intraoperatively applied glucocorticoid hydrogels on residual hearing and foreign body reaction in a guinea pig model of cochlear implantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracochlear drug delivery in combination with cochlear implants : Current aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intratympanic Triamcinolone and Dexamethasone in the Treatment of Ménière's Syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological therapies in otology

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnostics and Therapy of Idiopathic Sudden Sensorineural Hearing Loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Communication pathways to and from the inner ear and their contributions to drug delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29551306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.HEARES.2018.03.002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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