The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy. (Q64883689)

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English	The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy.	scientific article

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

2 references

6 November 2020

16 July 2021

The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

muscular disease

6 references

30 June 2019

14 September 2019

28 September 2019

16 November 2019

11 December 2019

6 November 2020

genetic variation

1 reference

14 September 2019

1 reference

28 September 2019

macromolecular substance

1 reference

16 November 2019

contractile proteins

1 reference

11 December 2019

cytoskeletal proteins

1 reference

11 December 2019

1 reference

6 November 2020

1 reference

16 July 2021

Steven B Marston

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

author name string

Steven Marston

1

1 reference

Europe PubMed Central

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30 June 2019

http://europepmc.org/abstract/PMC/6073311

language of work or name

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publication date

11 July 2018

8 references

30 June 2019

14 September 2019

28 September 2019

16 November 2019

11 December 2019

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

6 November 2020

16 July 2021

International Journal of Molecular Sciences

8 references

30 June 2019

14 September 2019

28 September 2019

16 November 2019

11 December 2019

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

6 November 2020

16 July 2021

19

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

copyright license

Creative Commons Attribution

7 references

30 June 2019

14 September 2019

28 September 2019

16 November 2019

11 December 2019

6 November 2020

16 July 2021

copyright status

0 references

Natural history of hypertrophic cardiomyopathy in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro motility analysis of actin-tropomyosin regulation by troponin and calcium. The thin filament is switched as a single cooperative unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of actin function

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steric-model for activation of muscle thin filaments 1 1 Edited by P.E. Wright

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of mutant myosins of Dictyostelium discoideum equivalent to human familial hypertrophic cardiomyopathy mutants. Molecular force level of mutant myosins may have a prognostic implication

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The muscle thin filament as a classical cooperative/allosteric regulatory system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tropomyosin and troponin regulation of wild type and E93K mutant actin filaments from Drosophila flight muscle. Charge reversal on actin changes actin-tropomyosin from on to off state

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in the ratio of mutant to wildtype myosin heavy chain present in the soleus muscle of patients with familial hypertrophic cardiomyopathy. A new approach for the quantification of mutant to wildtype protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Genetic Basis for Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of Diastolic Function With Doppler Tissue Imaging to Predict Genotype in Preclinical Hypertrophic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of human skeletal alpha-actin proteins by the baculovirus expression system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle disease caused by mutations in the skeletal muscle alpha-actin gene (ACTA1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterisation of a mutant actin (Met132Val) from a patient with nemaline myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a nonpolymerizable actin mutant in Sf9 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive analysis of the beta-myosin heavy chain gene in 389 unrelated patients with hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sarcomeric protein mutations in dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal hypertrophic cardiomyopathy and nemaline myopathy associated with ACTA1 K336E mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nemaline myopathy caused by absence of alpha-skeletal muscle actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of ACTA1-related congenital fiber type disproportion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-cardiac actin mutations produce atrial septal defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotype-phenotype correlations in ACTA1 mutations that cause congenital myopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From genotype to phenotype: a longitudinal study of a patient with hypertrophic cardiomyopathy due to a mutation in the MYBPC3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations and polymorphisms of the skeletal muscle alpha-actin gene (ACTA1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of a unique troponin c mutation, GLY159ASP, that causes familial dilated cardiomyopathy, studied in explanted heart muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional diversity among a family of human skeletal muscle myosin motors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into human beta-cardiac myosin function from single molecule and single cell studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: Mechanisms and therapeutic opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and interactions of myosin-binding protein C domain C0: cardiac-specific regulation of myosin at its neck?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inherited Cardiomyopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How do MYBPC3 mutations cause hypertrophic cardiomyopathy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nemaline myopathy with stiffness and hypertonia associated with an ACTA1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosinopathies: pathology and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomic model of the human cardiac muscle myosin filament.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dilated cardiomyopathy: the complexity of a diverse genetic architecture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural implications of β-cardiac myosin heavy chain mutations in human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy landscapes reveal the myopathic effects of tropomyosin mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic nomenclature for mammalian tropomyosin isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of muscle thin filament cooperativity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of super-relaxed myosin in skeletal and cardiac muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Switching Muscles On and Off in Steps: The McKillop-Geeves Three-State Model of Muscle Regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age- and strain-related aberrant Ca2+ release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thick Filament Protein Network, Functions, and Disease Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/29997361

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS19072020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29997361%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

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