Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity (Q64230383)

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scientific article published on 01 March 2019

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English	Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity	scientific article published on 01 March 2019

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scholarly article

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21 April 2020

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity (English)

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21 April 2020

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Deanne H Hryciw

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21 April 2020

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Anna C Simcocks

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21 April 2020

Kayte A Jenkin

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21 April 2020

Lannie O'Keefe

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21 April 2020

Chrishan S Samuel

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21 April 2020

Michael L Mathai

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21 April 2020

Andrew J McAinch

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21 April 2020

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1 March 2019

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21 April 2020

Endocrine Connections

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21 April 2020

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21 April 2020

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21 April 2020

203-216

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21 April 2020

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Creative Commons Attribution 4.0 International

1 March 2019

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Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin and the regulation of body weight in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

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Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis [seecomments]

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and weight control: the evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver enzyme alteration: a guide for clinicians.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the peripheral endocannabinoid system in human obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal effects of long-term leptin infusion and preventive role of losartan treatment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-fat diets: modeling the metabolic disorders of human obesity in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The orphan receptor GPR55 is a novel cannabinoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity, diabetes, and chronic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endocannabinoid system in obesity and type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of collagen content, concentration, and sub-types in kidney tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for cannabinoid receptors in human proximal tubular hypertrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potential role for GPR55 in gastrointestinal functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical experiences with cannabinoids in spasticity management in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute leptin exposure reduces megalin expression and upregulates TGFβ1 in cultured renal proximal tubule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction: activation of GPR55 receptors exacerbates oxLDL-induced lipid accumulation and inflammatory responses, while reducing cholesterol efflux from human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabidiol promotes browning in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30707678

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1530/EC-18-0535

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Europe PubMed Central

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21 April 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707678%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707678%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

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