Glycans as Key Checkpoints of T Cell Activity and Function (Q59806973)

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13 April 2020

review article

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title

Glycans as Key Checkpoints of T Cell Activity and Function (English)

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12 October 2019

hemic and immune systems

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18 October 2019

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18 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30538706%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

Manuel Vicente

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13 April 2020

Mariana C Silva

series ordinal

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13 April 2020

Nuno A Padrão

series ordinal

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13 April 2020

Salomé S Pinho

series ordinal

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language of work or name

English

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publication date

27 November 2018

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12 October 2019

18 October 2019

18 November 2019

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13 April 2020

published in

Frontiers in Immunology

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12 October 2019

18 October 2019

18 November 2019

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volume

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page(s)

2754

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Creative Commons Attribution 4.0 International

13 April 2020

3 references

12 October 2019

18 October 2019

Aerobic glycolysis during lymphocyte proliferation

18 November 2019

cites work

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12 December 2020

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

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12 December 2020

CD45 alternative exon expression in murine and human CD4+ T cell subsets

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12 December 2020

Site-directed mutagenesis of class I HLA genes. Role of glycosylation in surface expression and functional recognition

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12 December 2020

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system

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12 December 2020

c-Myc Is Glycosylated at Threonine 58, a Known Phosphorylation Site and a Mutational Hot Spot in Lymphomas

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12 December 2020

Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages

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12 December 2020

Alterations in CD45 glycosylation pattern accompanying different cell proliferation states

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12 December 2020

Expression of galectin-3 modulates T-cell growth and apoptosis

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12 December 2020

Activity levels of a β1,6 N-acetylglucosaminyltransferase in lymphomonocytes from multiple sclerosis patients

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12 December 2020

Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45

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12 December 2020

Roles for glycosylation of cell surface receptors involved in cellular immune recognition

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12 December 2020

Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats

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12 December 2020

Genetic remodeling of protein glycosylation in vivo induces autoimmune disease

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12 December 2020

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

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12 December 2020

Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

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12 December 2020

Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding

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12 December 2020

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

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12 December 2020

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

1 reference

12 December 2020

UDP-GlcNAc concentration is an important factor in the biosynthesis of beta1,6-branched oligosaccharides: regulation based on the kinetic properties of N-acetylglucosaminyltransferase V.

1 reference

12 December 2020

T-cell regulation by CD28 and CTLA-4.

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12 December 2020

Sweet 'n' sour: the impact of differential glycosylation on T cell responses

1 reference

12 December 2020

CD45: a critical regulator of signaling thresholds in immune cells

1 reference

12 December 2020

N-glycan branching requirement in neuronal and postnatal viability

1 reference

12 December 2020

Galectin-1 Sensitizes Resting Human T Lymphocytes to Fas (CD95)-mediated Cell Death via Mitochondrial Hyperpolarization, Budding, and Fission

1 reference

12 December 2020

Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells

1 reference

12 December 2020

Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

1 reference

12 December 2020

Immunobiology of muscle: advances in understanding an immunological microenvironment

1 reference

12 December 2020

Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin.

1 reference

12 December 2020

Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats

1 reference

12 December 2020

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

12 December 2020

Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response

1 reference

12 December 2020

The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

1 reference

12 December 2020

Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death

1 reference

12 December 2020

Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions

1 reference

12 December 2020

Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.

1 reference

12 December 2020

Specificity of DC-SIGN for mannose- and fucose-containing glycans

1 reference

12 December 2020

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

1 reference

12 December 2020

Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion

1 reference

12 December 2020

Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.

1 reference

12 December 2020

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

1 reference

12 December 2020

Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis

1 reference

12 December 2020

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

1 reference

12 December 2020

Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis

1 reference

12 December 2020

N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.

1 reference

12 December 2020

Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation.

1 reference

12 December 2020

Protein-glycan interactions in the control of innate and adaptive immune responses

1 reference

12 December 2020

Disruption of thymopoiesis in ST6Gal I-deficient mice

1 reference

12 December 2020

Alteration of N-glycosylation in the kidney in a mouse model of systemic lupus erythematosus: relative quantification of N-glycans using an isotope-tagging method

1 reference

12 December 2020

Mammalian glycosylation in immunity

1 reference

12 December 2020

O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors

1 reference

12 December 2020

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain

1 reference

12 December 2020

Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model

1 reference

12 December 2020

Sialic acids in T cell development and function

1 reference

12 December 2020

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

1 reference

12 December 2020

Adaptive regulation at the cell surface by N-glycosylation.

1 reference

12 December 2020

Critical role of glycosylation in determining the length and structure of T cell epitopes

1 reference

12 December 2020

MGAT5 alters the severity of multiple sclerosis

1 reference

12 December 2020

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

1 reference

12 December 2020

Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands but Does Not Overcome Defective Pre-TCR Signaling during Thymocyte β-Selection In Vivo

1 reference

12 December 2020

Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.

1 reference

12 December 2020

Galectin-9 regulates T helper cell function independently of Tim-3.

1 reference

12 December 2020

MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation

1 reference

12 December 2020

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

1 reference

12 December 2020

Mechanisms of T cell development and transformation.

1 reference

12 December 2020

When galectins recognize glycans: from biochemistry to physiology and back again

1 reference

12 December 2020

N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis

1 reference

12 December 2020

T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival

1 reference

12 December 2020

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner

1 reference

12 December 2020

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

1 reference

12 December 2020

A two-way street: reciprocal regulation of metabolism and signalling.

1 reference

12 December 2020

Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated

1 reference

12 December 2020

Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation

1 reference

12 December 2020

Glycobiology of immune responses

1 reference

12 December 2020

Metabolic checkpoints in activated T cells

1 reference

12 December 2020

The integration of signaling and the spatial organization of the T cell synapse

1 reference

12 December 2020

NETs: the missing link between cell death and systemic autoimmune diseases?

1 reference

12 December 2020

Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

1 reference

12 December 2020

The regulatory power of glycans and their binding partners in immunity

1 reference

12 December 2020

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion

1 reference

12 December 2020

Probing the hexosamine biosynthetic pathway in human tumor cells by multitargeted tandem mass spectrometry

1 reference

12 December 2020

Secretory IgA induces tolerogenic dendritic cells through SIGNR1 dampening autoimmunity in mice.

1 reference

12 December 2020

Adaptive immune activation: glycosylation does matter

1 reference

12 December 2020

Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis.

1 reference

12 December 2020

Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells

1 reference

12 December 2020

An overview of the intrathymic intricacies of T cell development

1 reference

12 December 2020

CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

1 reference

12 December 2020

Sialyl-tn in cancer: (how) did we miss the target?

1 reference

12 December 2020

Finding the sweet spot: assembly and glycosylation of the dystrophin-associated glycoprotein complex

1 reference

12 December 2020

Siglec-mediated regulation of immune cell function in disease.

1 reference

12 December 2020

N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling

1 reference

12 December 2020

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

1 reference

12 December 2020

Minireview series on the thirtieth anniversary of research on O-GlcNAcylation of nuclear and cytoplasmic proteins: Nutrient regulation of cellular metabolism and physiology by O-GlcNAcylation

1 reference

12 December 2020

Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells

1 reference

12 December 2020

Versatile characterization of glycosylation modification in CTLA4-Ig fusion proteins by liquid chromatography-mass spectrometry

1 reference

12 December 2020

Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review

1 reference

12 December 2020

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

1 reference

12 December 2020

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

1 reference

12 December 2020

IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.

1 reference

12 December 2020

Glycosylation in cancer: mechanisms and clinical implications

1 reference

12 December 2020

Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25.

1 reference

12 December 2020

Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer

1 reference

12 December 2020

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development

1 reference

12 December 2020

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

1 reference

12 December 2020

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.

1 reference

12 December 2020

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

1 reference

12 December 2020

Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

1 reference

12 December 2020

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways

1 reference

12 December 2020

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

1 reference

12 December 2020

Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx

1 reference

12 December 2020

Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.

1 reference

12 December 2020

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

1 reference

12 December 2020

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.

1 reference

12 December 2020

Metabolic pathways in T cell activation and lineage differentiation

1 reference

12 December 2020

T Cell Development by the Numbers.

1 reference

12 December 2020

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.

1 reference

12 December 2020

Functions of galectins as 'self/non-self'-recognition and effector factors

1 reference

12 December 2020

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

1 reference

12 December 2020

The Mechanisms of T Cell Selection in the Thymus.

1 reference

12 December 2020

Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4+ Regulatory T Cells and Their Suppressive Function.

1 reference

12 December 2020

Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle.

1 reference

12 December 2020

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.

1 reference

12 December 2020

Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

1 reference

12 December 2020

The tumour glyco-code as a novel immune checkpoint for immunotherapy

1 reference

12 December 2020

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

1 reference

12 December 2020

Human T Cell Development, Localization, and Function throughout Life

1 reference

12 December 2020

Skeletal muscle cells actively shape (auto)immune responses.

1 reference

12 December 2020

Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis.

1 reference

12 December 2020

C-type lectins in immunity and homeostasis

1 reference

12 December 2020

Risk factors and disease mechanisms in myositis.

1 reference

12 December 2020

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

1 reference

12 December 2020

MAN1B-CDG: Novel variants with a distinct phenotype and review of literature

1 reference

12 December 2020

Glycans as critical regulators of gut immunity in homeostasis and disease

1 reference

12 December 2020

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

1 reference

12 December 2020

A [Glyco]biomarker that Predicts Failure to Standard Therapy in Ulcerative Colitis Patients

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2018.02754

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30538706%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30538706%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

PubMed publication ID

30538706

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30538706%20AND%20SRC:MED&resulttype=core&format=json