Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. (Q48180638)

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scientific article

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English	Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.	scientific article

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17475804%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17475804%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

lipopolysaccharide

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Hyun B Choi

1

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30 December 2019

Jae K Ryu

2

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30 December 2019

Seung U Kim

3

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30 December 2019

James G McLarnon

4

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30 December 2019

language of work or name

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1 May 2007

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30 December 2019

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12

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Journal of Neuroscience

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30 December 2019

27

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30 December 2019

18

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30 December 2019

4957-4968

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30 December 2019

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death

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https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

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Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor

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https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

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Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia

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https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

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Interleukin 1 in the brain: biology, pathology and therapeutic target

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12 December 2020

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

1 reference

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12 December 2020

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Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute actions of tumor necrosis factor-alpha on intracellular Ca(2+) and K(+) currents in human microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Inhibition of store-operated Ca(2+) influx by acidic extracellular pH in cultured human microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines

1 reference

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12 December 2020

based on heuristic

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Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia

1 reference

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12 December 2020

based on heuristic

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Prothrombin kringle-2 activates cultured rat brain microglia

1 reference

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12 December 2020

based on heuristic

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Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease

1 reference

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12 December 2020

based on heuristic

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Calcium signaling in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells

1 reference

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12 December 2020

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Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

1 reference

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12 December 2020

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Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor‐independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

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Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 receptor modulation of beta-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 receptors control 2-arachidonoylglycerol production by microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 receptor inhibition improves recovery after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 receptor expression after ischemia in the cerebral cortex of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated cerebral ischemic injury by activated macrophages/microglia after lipopolysaccharide microinjection into rat corpus callosum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purinergic mediated changes in Ca2+ mobilization and functional responses in microglia: effects of low levels of ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue distribution of the P2X7 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-mediated cytotoxicity in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475804

12 December 2020

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Identifiers

10.1523/JNEUROSCI.5417-06.2007

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17475804%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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24 November 2022

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17475804%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17475804%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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