A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer (Q46490111)

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scientific article published on 11 July 2008

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English	A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer	scientific article published on 11 July 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

title

A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer (English)

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

author name string

Hedy Lee Kindler

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1

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Europe PubMed Central

PubMed publication ID

18618081

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22 December 2017

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http://europepmc.org/abstract/MED/18618081

Howard A Burris

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2

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Europe PubMed Central

PubMed publication ID

18618081

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22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

Alan B Sandler

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3

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Europe PubMed Central

PubMed publication ID

18618081

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22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

Ira Anton Oliff

series ordinal

4

1 reference

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

publication date

11 July 2008

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

published in

Investigational New Drugs

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stated in

Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

volume

27

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

issue

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

page(s)

75-81

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Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

cites work

Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS10637-008-9160-1

retrieved

21 January 2018

Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma

1 reference

stated in

Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS10637-008-9160-1

retrieved

21 January 2018

A phase II study of alanosine in advanced large bowel carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alanosine (UCSD)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimal two-stage designs for phase II clinical trials

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of methylthioadenosine phosphorylase in human gliomas

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alanosine, a new antiviral and antitumour agent isolated from a Streptomyces

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of L-alanosine using a daily x 3 schedule

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II clinical trial of L-alanosine in advanced upper aerodigestive cancer.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of L-alanosine (NSC 15353)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18618081

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S10637-008-9160-1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

PubMed publication ID

18618081

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18618081

retrieved

22 December 2017

reference URL

http://europepmc.org/abstract/MED/18618081

 

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