Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation (Q46287146)

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scientific article published in October 2008

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English	Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation	scientific article published in October 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Simvastatin impairs humoral and cell-mediated immunity in mice by inhibiting lymphocyte homing, T-cell activation and antigen cross-presentation (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

1 reference

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author name string

Cristina Ulivieri

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Daniela Fanigliulo

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Daniela Benati

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Franco Laghi Pasini

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Cosima T Baldari

5

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

language of work or name

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publication date

1 October 2008

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

European Journal of Immunology

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

38

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

2832-2844

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model

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Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice

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Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction

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Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesis.

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Small rho GTPases regulate antigen presentation in dendritic cells

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Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering

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T lymphocytes as targets of statins: molecular mechanisms and therapeutic perspectives

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GTPases and T cell activation

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

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Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases.

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Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis

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Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

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Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

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Statins in the treatment of central nervous system autoimmune disease

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HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation

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The effects of atorvastatin in experimental autoimmune uveitis

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Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic -Cell-Specific CD8 T-Cells

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HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

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Statins as a newly recognized type of immunomodulator

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Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

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Differential effects of statins on relevant functions of human monocyte-derived dendritic cells

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Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases.

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Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9.

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Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

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Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

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T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs

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Statins inhibit lymphocyte homing to peripheral lymph nodes

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Lymphocyte trafficking across high endothelial venules: dogmas and enigmas

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Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin

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Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo

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Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.

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Contact hypersensitivity

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

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p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis

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Identifiers

10.1002/EJI.200838278

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

release_fi7xjw24mjcwxkr3z2m2dowriy

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https://api.fatcat.wiki/v0/release/fi7xjw24mjcwxkr3z2m2dowriy

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18958884

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