mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. (Q44905183): Difference between revisions

7 December 2017

title

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. (English)

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7 December 2017

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Pradip K Majumder

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Phillip G Febbo

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Rachel Bikoff

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Raanan Berger

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7 December 2017

Qi Xue

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Louis M McMahon

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Judith Manola

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James Brugarolas

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Timothy J McDonnell

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Todd R Golub

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Massimo Loda

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Heidi A Lane

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William R Sellers

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7 December 2017

language of work or name

English

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publication date

23 May 2004

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7 December 2017

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page(s)

594-601

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 December 2017

cites work

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Direct control of the Forkhead transcription factor AFX by protein kinase B

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

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Early clinical experience with a novel rapamycin derivative

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Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

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The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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Signal transduction to hypoxia-inducible factor 1

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High frequency of mutations of the PIK3CA gene in human cancers

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PIK3CA is implicated as an oncogene in ovarian cancer.

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The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

21 January 2018

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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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Bcl-2 proto-oncogene expression in low- and high-grade prostatic intraepithelial neoplasia

21 January 2018

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PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression

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Mammalian target of rapamycin: a new molecular target for breast cancer

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

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Targeting HIF-1 for cancer therapy

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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21 January 2018

Identifiers

DOI

10.1038/NM1052

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7 December 2017

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