Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity (Q42808394)

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scientific article published on 11 November 2002

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English	Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity	scientific article published on 11 November 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

author name string

Jeffrey C Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Shunhui Zhuang

2

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Tony H Nguyen

3

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Gerry R Boss

4

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Renate B Pilz

5

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Europe PubMed Central

PubMed publication ID

7 November 2017

language of work or name

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publication date

11 November 2002

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Europe PubMed Central

PubMed publication ID

7 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

7 November 2017

278

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Europe PubMed Central

PubMed publication ID

7 November 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

2807-2818

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Europe PubMed Central

PubMed publication ID

7 November 2017

Ras activation in human breast cancer

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Hyperexpression of mitogen-activated protein kinase in human breast cancer

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RHO-GTPases and cancer

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Signaling to Rho GTPases

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A role for Rho in Ras transformation

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

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An essential role for Rac in Ras transformation

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

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Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

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Signaling from Ras to Rac and beyond: not just a matter of GEFs

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Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

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Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

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Rac mediates growth factor-induced arachidonic acid release.

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Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts

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Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

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Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

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Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

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Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions

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Multiple Ras functions can contribute to mammalian cell transformation

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Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

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Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

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The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments

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Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

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Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells

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Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

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Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Rapid recruitment of p120RasGAP and its associated protein, p190RhoGAP, to the cytoskeleton during integrin mediated cell-substrate interaction

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Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates.

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Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress

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Cadherin engagement regulates Rho family GTPases

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Differential activation of the Rac pathway by Ha-Ras and K-Ras

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

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Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

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A cytosolic protein catalyzes the release of GDP from p21ras

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Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

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Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain

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Role of p120 Ras-GAP in directed cell movement

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Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

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Increasing complexity of Ras signaling.

1 reference

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Rho GTPases are over-expressed in human tumors.

1 reference

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

1 reference

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A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts

1 reference

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Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization

1 reference

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The role of Mg2+ cofactor in the guanine nucleotide exchange and GTP hydrolysis reactions of Rho family GTP-binding proteins

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Rho as a mediator of G protein-coupled receptor signaling.

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Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

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Identifiers

10.1074/JBC.M207943200

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

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