Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals (Q42719353)

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scientific article published on 19 December 2006

Language	Label	Description	Also known as
English	Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals	scientific article published on 19 December 2006

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals (English)

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Europe PubMed Central

PMC publication ID

5 November 2017

1 reference

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inferred from title

author name string

Eric E Swayze

1

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Andrew M Siwkowski

2

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Edward V Wancewicz

3

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Michael T Migawa

4

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Tadeusz K Wyrzykiewicz

5

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Gene Hung

6

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Brett P Monia

7

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Europe PubMed Central

PMC publication ID

5 November 2017

C Frank Bennett

8

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Europe PubMed Central

PMC publication ID

5 November 2017

language of work or name

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publication date

19 December 2006

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5 November 2017

Nucleic Acids Research

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Europe PubMed Central

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5 November 2017

35

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Europe PubMed Central

PMC publication ID

5 November 2017

2

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

687-700

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Direct comparison of in vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA with that of 2'-O-(2-methoxy)ethyl-modified oligonucleotides

1 reference

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

1 reference

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Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice

1 reference

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An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

1 reference

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A functionally improved locked nucleic acid antisense oligonucleotide inhibits Bcl-2 and Bcl-xL expression and facilitates tumor cell apoptosis.

1 reference

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Sequence-dependent cytotoxicity of second-generation oligonucleotides.

1 reference

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Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

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Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs

1 reference

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Tissue disposition of 2'-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys

1 reference

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Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

1 reference

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27 May 2018

p53 has a direct apoptogenic role at the mitochondria

1 reference

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27 May 2018

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

1 reference

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1 reference

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Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

1 reference

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Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides

1 reference

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Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

1 reference

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27 May 2018

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

1 reference

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27 May 2018

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

1 reference

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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

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27 May 2018

Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity

1 reference

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27 May 2018

Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?

1 reference

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27 May 2018

A DNA damage signal is required for p53 to activate gadd45.

1 reference

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27 May 2018

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

1 reference

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27 May 2018

Quantitation of phosphorothioate oligonucleotides in human plasma

1 reference

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27 May 2018

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802611

27 May 2018

Physicochemical properties of phosphorothioate oligodeoxynucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802611

27 May 2018

Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms

1 reference

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Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

1 reference

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Development of siRNA for therapeutics: efficient synthesis of phosphorothioate RNA utilizing phenylacetyl disulfide (PADS).

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Kilo-scale synthesis process for 2'-O-(2-methoxyethyl)-pyrimidine derivatives

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A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer

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1 reference

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1 reference

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1 reference

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1 reference

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On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti-H-Ras Antisense Oligonucleotide

1 reference

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Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKL1071

21 January 2018

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKL1071

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A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17182632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17182632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKL1071

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

ResearchGate publication ID

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