Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. (Q42796344): Difference between revisions

14 June 2018

title

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. (English)

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14 June 2018

author name string

Xiaofeng Wu

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14 June 2018

Li-Shu Zhang

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14 June 2018

Jason Toombs

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14 June 2018

Yi-Chun Kuo

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14 June 2018

John Tyler Piazza

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14 June 2018

Rubina Tuladhar

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14 June 2018

Quinn Barrett

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14 June 2018

Chih-Wei Fan

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14 June 2018

Xuewu Zhang

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14 June 2018

Loren D Walensky

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14 June 2018

Marcel Kool

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14 June 2018

Steven Y Cheng

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14 June 2018

Rolf Brekken

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14 June 2018

Joseph T Opferman

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14 June 2018

Douglas R Green

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14 June 2018

Tudor Moldoveanu

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14 June 2018

Lawrence Lum

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14 June 2018

publication date

25 September 2017

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14 June 2018

published in

Nature Cell Biology

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14 June 2018

volume

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14 June 2018

issue

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14 June 2018

page(s)

1226-1236

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14 June 2018

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

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PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition

15 June 2018

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BID-induced structural changes in BAK promote apoptosis

15 June 2018

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

15 June 2018

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A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival

15 June 2018

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A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia

15 June 2018

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Novel mutations target distinct subgroups of medulloblastoma.

15 June 2018

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15 June 2018

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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

15 June 2018

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Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

15 June 2018

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15 June 2018

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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

15 June 2018

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Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium

15 June 2018

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Functional characterization of putative cilia genes by high-content analysis

15 June 2018

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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

15 June 2018

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15 June 2018

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

15 June 2018

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15 June 2018

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Apoptotic Regulation by MCL-1 through Heterodimerization

15 June 2018

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

15 June 2018

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15 June 2018

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15 June 2018

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Hedgehog beyond medulloblastoma and basal cell carcinoma

15 June 2018

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

15 June 2018

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

15 June 2018

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Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

15 June 2018

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Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle

15 June 2018

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Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

15 June 2018

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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

15 June 2018

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Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

15 June 2018

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Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

15 June 2018

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Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

15 June 2018

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15 June 2018

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15 June 2018

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

15 June 2018

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Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia.

15 June 2018

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Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors

16 June 2018

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Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

16 June 2018

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MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.

16 June 2018

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16 June 2018

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Amplification of the gli gene in childhood sarcomas.

16 June 2018

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The whole-genome landscape of medulloblastoma subtypes

3 July 2018

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A BH3 Mimetic for Killing Cancer Cells

16 August 2018

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Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

16 August 2018

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Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

16 August 2018

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Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

16 August 2018

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The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function.

16 August 2018

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Gene expression analyses reveal molecular relationships among 20 regions of the human CNS.

16 August 2018

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Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

16 August 2018

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

16 August 2018

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Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

16 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNCB3616

21 January 2018

Identifiers

DOI

10.1038/NCB3616

1 reference

14 June 2018

PMC publication ID

5657599

1 reference

14 June 2018

PubMed publication ID

28945232

1 reference

14 June 2018