Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia (Q40321458)

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scientific article published on 18 April 2016

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English	Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia	scientific article published on 18 April 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia (English)

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

0 references

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Andrea Cabrera-Pastor

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27090509%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

5

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3 June 2020

Tiziano Balzano

6

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3 June 2020

8

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3 June 2020

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Vicente Hernandez-Rabaza

1

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3 June 2020

Lucas Taoro-Gonzalez

3

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3 June 2020

Alba Gonzalez-Usano

4

1 reference

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3 June 2020

Marta Llansola

7

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3 June 2020

publication date

18 April 2016

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19 September 2017

Journal of Neuroinflammation

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3 June 2020

13

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3 June 2020

1

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3 June 2020

83

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27090509%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Hyperinsulinism Hyperammonemia Syndrome, a Rare Clinical Constellation

1 reference

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22 September 2017

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Morphological changes of cortical pyramidal neurons in hepatic encephalopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Hepatic encephalopathy: effects of liver failure on brain function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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High incidence of symptomatic hyperammonemia in children with acute lymphoblastic leukemia receiving pegylated asparaginase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Experimental models of hepatic encephalopathy: ISHEN guidelines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

The transcription factor Nrf2 is a therapeutic target against brain inflammation

1 reference

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22 September 2017

Hospitalizations during the use of rifaximin versus lactulose for the treatment of hepatic encephalopathy

1 reference

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22 September 2017

Attention, memory, and cognitive function in hepatic encephalopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Neurobiology of ammonia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Urea cycle disorders, hyperammonemia and neurotransmitter changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

22 September 2017

Role for pro-inflammatory cytokines in regulating expression of GABA transporter type 1 and 3 in specific brain regions of kainic acid-induced status epilepticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

25 September 2017

Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

15 June 2018

Hyperammonemia and Reye's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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A Nationwide Survey on Transient Hyperammonemia in Newborn Infants in Japan: Prognosis of Life and Neurological Outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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Transient hyperammonemia of the preterm infant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy

1 reference

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Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835883

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1 reference

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1 reference

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Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamoyl-phosphate synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia activation in hepatic encephalopathy in rats and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain

1 reference

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Induction of rat brain tubulin following ammonium ingestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27090509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12974-016-0549-Z

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27090509%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12974-016-0549-z

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27090509%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27090509%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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