A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma. (Q40179159)

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scientific article published on September 2007

Language	Label	Description	Also known as
English	A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma.	scientific article published on September 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

J McCleese

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

S Kamerling

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

J Christensen

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

C A London

5

1 reference

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7 February 2020

publication date

1 September 2007

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Veterinary and Comparative Oncology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

3

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7 February 2020

177-196

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7 February 2020

Tyrosine kinase receptor indistinguishable from the c-met protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

1 reference

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21 January 2018

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor

1 reference

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21 January 2018

Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Scatter factor induces blood vessel formation in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Met, metastasis, motility and more

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

The met proto-oncogene receptor and lumen formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Scatter factor/hepatocyte growth factor is essential for liver development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

A novel germ line juxtamembrane Met mutation in human gastric cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Papillary renal cell carcinoma: analysis of germline mutations in the MET proto-oncogene in a clinic-based population

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Small molecules with EGFR-TK inhibitor activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Characterization, expression and function of c-Met in canine spontaneous cancers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Incidence of malignant disease by morphological type, in young persons aged 12-24 years in England, 1979-1997.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

c-Met: structure, functions and potential for therapeutic inhibition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Met receptor tyrosine kinase: enhanced signaling through adapter proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5829.2007.00137.X

21 January 2018

Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility

1 reference

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21 January 2018

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1 reference

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21 January 2018

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1 reference

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21 January 2018

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

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21 January 2018

The treatment of osteosarcoma of the extremities: twenty year's experience at the Istituto Ortopedico Rizzoli

1 reference

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21 January 2018

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

1 reference

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21 January 2018

A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells

1 reference

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21 January 2018

Identifiers

10.1111/J.1476-5829.2007.00137.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19754789%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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