Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. (Q40071304)

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Language	Label	Description	Also known as
English	Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

author name string

Stephanie J Turner

1

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Shunhui Zhuang

2

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Tong Zhang

3

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Gerry R Boss

4

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Renate B Pilz

5

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

publication date

1 September 2007

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Biochemical Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

75

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

405-413

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Mechanisms of statin-mediated inhibition of small G-protein function

1 reference

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22 September 2017

RhoGDI: multiple functions in the regulation of Rho family GTPase activities

1 reference

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22 September 2017

Rho GDP dissociation inhibitor protects cancer cells against drug-induced apoptosis

1 reference

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22 September 2017

Pleiotropic effects of statins

1 reference

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22 September 2017

Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities

1 reference

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Statins inhibit HIV-1 infection by down-regulating Rho activity.

1 reference

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22 September 2017

Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.

1 reference

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Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes

1 reference

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RHO-GTPases and cancer

1 reference

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22 September 2017

RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.

1 reference

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22 September 2017

cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions

1 reference

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HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

1 reference

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

1 reference

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22 September 2017

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

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22 September 2017

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

1 reference

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22 September 2017

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity

1 reference

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22 September 2017

RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

1 reference

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22 September 2017

A novel role for RhoGDI as an inhibitor of GAP proteins

1 reference

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The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

1 reference

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Phase separation of integral membrane proteins in Triton X-114 solution

1 reference

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22 September 2017

Cell cycle-specific effects of lovastatin

1 reference

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22 September 2017

Post-translational modifications of p21rho proteins

1 reference

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22 September 2017

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

1 reference

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25 September 2017

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1 reference

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25 September 2017

HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2228324

17 June 2018

RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2228324

17 June 2018

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1 reference

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17 June 2018

Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2228324

20 August 2018

Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo

1 reference

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Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells

1 reference

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Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA.

1 reference

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20 August 2018

Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis.

1 reference

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20 August 2018

Oncogenic Ras leads to Rho activation by activating the mitogen-activated protein kinase pathway and decreasing Rho-GTPase-activating protein activity

1 reference

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20 August 2018

Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice

1 reference

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20 August 2018

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

1 reference

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20 August 2018

Role of prenylation in the interaction of Rho-family small GTPases with GTPase activating proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2228324

20 August 2018

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

1 reference

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20 August 2018

Identifiers

10.1016/J.BCP.2007.08.031

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

ResearchGate publication ID

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