Abstract
Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Nucleolus / physiology
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Cell Nucleolus / ultrastructure
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Cell Nucleus / chemistry
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Cell Nucleus / physiology*
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Cell Nucleus / ultrastructure*
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Chromatin / physiology
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Chromosomes / physiology
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Drosophila Proteins*
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Euchromatin
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Gene Expression Regulation
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Heterochromatin / physiology
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Humans
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Insect Proteins / chemistry
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Insect Proteins / physiology
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Interphase
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / physiology
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Nuclear Proteins*
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Polycomb Repressive Complex 1
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Polycomb-Group Proteins
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Promyelocytic Leukemia Protein
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Repressor Proteins / chemistry
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Repressor Proteins / physiology
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Ribonucleoproteins, Small Nuclear / analysis
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Ribonucleoproteins, Small Nuclear / physiology
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Transcription Factors / chemistry
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Transcription Factors / physiology
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Tumor Suppressor Proteins
Substances
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Chromatin
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Drosophila Proteins
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Euchromatin
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Heterochromatin
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Insect Proteins
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Neoplasm Proteins
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Nuclear Proteins
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Pc protein, Drosophila
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Polycomb-Group Proteins
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Promyelocytic Leukemia Protein
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Repressor Proteins
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Ribonucleoproteins, Small Nuclear
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Transcription Factors
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Tumor Suppressor Proteins
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PML protein, human
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Polycomb Repressive Complex 1